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Literature summary extracted from

  • Keren, R.; Stark, A.A.
    gamma-Glutamyl transpeptidase-dependent mutagenicity and cytotoxicity of gamma-glutamyl derivatives: a model for biochemical targeting of chemotherapeutic agents (1998), Environ. Mol. Mutagen., 32, 377-386.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.2.2 medicine bioconversion of cytotoxic and mutagenic agents to inactive 5-L-glutamyl-derivatives Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 4-nitroaniline cytotoxic, weakly mutagenic Rattus norvegicus
2.3.2.2 5-glutamylphenylhydrazides no inhibition and cytotoxity Rattus norvegicus
2.3.2.2 daunomycin cytotoxic and mutagenic Rattus norvegicus
2.3.2.2 L- or D-Serine/borate competitive Rattus norvegicus
2.3.2.2 additional information
-
 Rattus norvegicus
2.3.2.2 phenylhydrazides cytotoxic and mutagenic Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.2 5-D/L-glutamyl-phenylhydrazine + acceptor Rattus norvegicus
-
 phenylhydrazine + 5-L-glutamyl-acceptor product is cytotoxic ir

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.2 a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid kinetic study Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ concurrent reaction: hydrolase reaction with H2O as acceptor Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ir
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ir
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ir
2.3.2.2 5-D/L-glutamyl-phenylhydrazine + acceptor
-
 Rattus norvegicus phenylhydrazine + 5-L-glutamyl-acceptor product is cytotoxic ir
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine
-
 Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine 4-nitroaniline is cytotoxic ?
2.3.2.2 glutathione + daunomycin detoxification of daunomycin by transpeptidation Rattus norvegicus L-cysteinylglycine + 5-L-glutamyl-daunomycin
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.3.2.2 GGT
-
 Rattus norvegicus