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Literature summary extracted from

  • Murthy, S.N.P.; Velasco, P.T.; Lorand, L.
    Properties of purified lens transglutaminase and regulation of its transamidase/crosslinking activity by GTP (1998), Exp. Eye Res., 67, 273-281.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 dithiothreitol
-
 Cavia porcellus
2.3.2.13 dithiothreitol required for activity of lens transglutaminase Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 GTP
-
 Cavia porcellus
2.3.2.13 GTP
-
 Homo sapiens
2.3.2.13 GTP 0.05 mM, 50% inhibition of lens transglutaminase, 0.5 mM, complete inhibition in the presence of 0.5 mM Ca2+, increasing the Ca2+ concentration to 3 mM reverses inhibition Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Cavia porcellus
2.3.2.13 Ca2+ requirement Homo sapiens
2.3.2.13 Ca2+ requirement Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 78000
-
 x * 78000, lens transglutaminase, SDS-PAGE Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-
2.3.2.13 Homo sapiens
-
-
-
2.3.2.13 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.13 lens transglutaminase, DE-52, affinity chromatography on 42000 Da thermolytic fragment of human plasma fibronectin Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 lens
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 monodansylcadaverine + N,N-dimethylcasein
-
 Oryctolagus cuniculus ?
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine
-
 Cavia porcellus protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine
-
 Homo sapiens protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine lens transglutaminase, crosslinking of beta-crystallin Oryctolagus cuniculus protein N5-alkylglutamine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.13 ?
-
 Homo sapiens
2.3.2.13 ? x * 78000, lens transglutaminase, SDS-PAGE Oryctolagus cuniculus