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Literature summary extracted from

  • Ichinose, A.; Bottenus, R.E.; Davie, E.W.
    Structure of transglutaminases (1990), J. Biol. Chem., 265, 13411-13414.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.13 cloning of factor XIII beta-subunit cDNA Homo sapiens
2.3.2.13 liver transglutaminase C Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 cytoplasm
-
 Cavia porcellus 5737
-
2.3.2.13 cytoplasm
-
 Homo sapiens 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 73183
-
 x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence Homo sapiens
2.3.2.13 75000
-
 75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits Homo sapiens
2.3.2.13 76620
-
 1 * 76620, liver transglutaminase, deduced from nucleotide sequence Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine Homo sapiens dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine Cavia porcellus production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum protein N5-alkylglutamine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-
2.3.2.13 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.13 additional information
-
 Cavia porcellus
2.3.2.13 additional information alpha-subunit of factor XIIIa is most probably not glycosylated Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Cavia porcellus
a
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 blood platelet uterus, macrophages Homo sapiens
-
2.3.2.13 blood platelet placenta Homo sapiens
-
2.3.2.13 placenta platelets Homo sapiens
-
2.3.2.13 placenta macrophages Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine dimerization of fibrin gamma chains, cross-linking of alpha2-plasmin inhibitor to fibrin alpha-chain and cross-linking of fibronectin to fibrin alpha-chains by factor XIIIa Homo sapiens protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine production of vaginal plug by postejaculatory clotting of rodent seminal plasma, formation of chemically resistant envelope of the stratum Cavia porcellus protein N5-alkylglutamine + NH3
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.13 ? x * 73183, factor XIII beta-subunit, deduced from nucleotide sequence Homo sapiens
2.3.2.13 monomer
-
 Homo sapiens
2.3.2.13 monomer 1 * 76620, liver transglutaminase, deduced from nucleotide sequence Cavia porcellus
2.3.2.13 More zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively Homo sapiens
2.3.2.13 More 75000 Da catalytically active alpha-subunits of plasma enzyme are stabilized by 80000 Da beta-subunits Homo sapiens
2.3.2.13 More tissue-type and epidermal TG are monomers, hair follicle TG and coagulation factor XIIIa, i.e. fibrinoligase, are dimers Homo sapiens