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Literature summary extracted from

  • Delcros, J.G.; Roch, A.M.; Quash, G.
    The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine (1984), FEBS Lett., 171, 221-226.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 alpha-difluoromethylornithine 2.6 mM, 50% inhibition of putrescine transfer to casein, suicide substrate, irreversible, competitive to putrescine or fibrinonectin Cavia porcellus
2.3.2.13 ornithine weak, suicide substrate in the presence of casein Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.13 0.17
-
 putrescine
-
 Cavia porcellus
2.3.2.13 1.35
-
 ornithine
-
 Cavia porcellus
2.3.2.13 2.1
-
 alpha-difluoromethylornithine
-
 Cavia porcellus
2.3.2.13 2.1
-
 alpha-difluoroornithine suicide substrate Cavia porcellus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 alpha-difluoromethylornithine + casein
-
 Cavia porcellus ?
-
 ?
2.3.2.13 alpha-difluoroornithine + casein suicide substrate Cavia porcellus ?
-
 ?
2.3.2.13 ornithine + casein
-
 Cavia porcellus ?
-
 ?
2.3.2.13 putrescine + casein in vitro acceptor Cavia porcellus ?
-
 ?
2.3.2.13 putrescine + fibronectin in vivo acceptor Cavia porcellus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.13 37
-
 assay at Cavia porcellus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.13 2.28
-
 alpha-difluoromethylornithine
-
 Cavia porcellus