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Literature summary extracted from

  • Takahashi, N.; Takahashi, Y.; Putnam, F.W.
    Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta (1986), Proc. Natl. Acad. Sci. USA, 83, 8019-8023.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 thrombin removes blocked NH2-terminal peptide of factor XIII and unmasks reactive thiol-group at Cys-314 to yield catalytically active factor XIIIa, i.e. fibrinoligase, from inactive zymogen XIII Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.13 cloning of placenta FXIIIa-gene cDNA Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Homo sapiens
2.3.2.13 Ca2+ Cys-thiol active binding-site identified Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 83005
-
x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence Homo sapiens
2.3.2.13 83010
-
primary structure Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine Homo sapiens last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.13 additional information no glycoprotein Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 mechanism and structure Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 blood plasma identical with enzyme from placenta or platelets Homo sapiens
-
2.3.2.13 blood platelet identical with enzyme from plasma Homo sapiens
-
2.3.2.13 blood platelet placenta Homo sapiens
-
2.3.2.13 placenta identical with enzyme from plasma Homo sapiens
-
2.3.2.13 placenta platelets Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrates are coagulation factor V, alpha2-macroglobulin, platelet myosin, actin Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrate fibronectin Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?

Subunits

EC Number Subunits Comment Organism
2.3.2.13 ? x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence Homo sapiens