EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.13 | thrombin | removes blocked NH2-terminal peptide of factor XIII and unmasks reactive thiol-group at Cys-314 to yield catalytically active factor XIIIa, i.e. fibrinoligase, from inactive zymogen XIII | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.2.13 | cloning of placenta FXIIIa-gene cDNA | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.13 | Ca2+ | requirement | Homo sapiens | |
2.3.2.13 | Ca2+ | Cys-thiol active binding-site identified | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.2.13 | 83005 | - |
x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence | Homo sapiens |
2.3.2.13 | 83010 | - |
primary structure | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | Homo sapiens | last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules | protein N5-alkylglutamine + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.2.13 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.3.2.13 | additional information | no glycoprotein | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.2.13 | protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | mechanism and structure | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.2.13 | blood plasma | identical with enzyme from placenta or platelets | Homo sapiens | - |
2.3.2.13 | blood platelet | identical with enzyme from plasma | Homo sapiens | - |
2.3.2.13 | blood platelet | placenta | Homo sapiens | - |
2.3.2.13 | placenta | identical with enzyme from plasma | Homo sapiens | - |
2.3.2.13 | placenta | platelets | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | substrates are coagulation factor V, alpha2-macroglobulin, platelet myosin, actin | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.2.13 | ? | x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence | Homo sapiens |