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Literature summary extracted from

  • Ferry, G.; Loynel, A.; Kucharczyk, N.; Bertin, S.; Rodriguez, M.; Delagrange, P.; Galizzi, J.P.; Jacoby, E.; Volland, J.P.; Lesieur, D.; Renard, P.; Canet, E.; Fauchere, J.L.; Boutin, J.A.
    Substrate specificity and inhibition studies of human serotonin N-acetyltransferase (2000), J. Biol. Chem., 275, 8794-8805.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.87 Melatonin IC50 0.16 mM Homo sapiens
2.3.1.87 additional information inhibition values of peptide inhibitors Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.87 0.11
-
tryptamine
-
Ovis aries
2.3.1.87 0.125
-
serotonin
-
Ovis aries
2.3.1.87 0.173
-
beta-phenylethylamine
-
Homo sapiens
2.3.1.87 0.18
-
acetyl-CoA
-
Ovis aries
2.3.1.87 0.2
-
5-methoxytryptamine
-
Homo sapiens
2.3.1.87 0.55
-
acetyl-CoA
-
Homo sapiens
2.3.1.87 0.91
-
tryptamine
-
Homo sapiens
2.3.1.87 1.23
-
serotonin
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Homo sapiens
-
recombinant enzyme
-
2.3.1.87 Ovis aries
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + 5-methoxytryptamine
-
Homo sapiens CoA + N-acetyl-5-methoxytryptamine
-
?
2.3.1.87 acetyl-CoA + beta-phenylethylamine
-
Homo sapiens CoA + N-(2-phenylethyl)-acetaminde
-
?
2.3.1.87 acetyl-CoA + beta-phenylethylamine
-
Ovis aries CoA + N-(2-phenylethyl)-acetaminde
-
?
2.3.1.87 acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Homo sapiens CoA + N-acetylserotonin
-
?
2.3.1.87 acetyl-CoA + serotonin i.e. 5-hydroxytryptamine Ovis aries CoA + N-acetylserotonin
-
?
2.3.1.87 acetyl-CoA + tryptamine
-
Homo sapiens CoA + N-acetyltryptamine
-
?
2.3.1.87 acetyl-CoA + tryptamine
-
Ovis aries CoA + N-acetyltryptamine
-
?
2.3.1.87 acetyl-CoA + tyramine very poor substrate Homo sapiens CoA + N-acetyltyramine
-
?
2.3.1.87 additional information
-
Ovis aries ?
-
?
2.3.1.87 additional information further substrates: selected synthetic amines Homo sapiens ?
-
?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.87 0.16
-
IC50 0.16 mM Homo sapiens Melatonin