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Literature summary extracted from

  • Tsukamoto, Y.; Wong, H.; Mattick, J.S.; Wakil, S.J.
    The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action (1983), J. Biol. Chem., 258, 15312-15322.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 cerulenin acetyl-CoA protects Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.85 additional information
-
 molecular weight of fragments after proteolytic cleavage Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.85
-
 Gallus gallus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Gallus gallus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Gallus gallus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.85 liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.85 1.2 1.6 NADPH Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.85 More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis and an acyl carrier site, arranged in three domains Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.85 4'-phosphopantetheine
-
 Gallus gallus