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Literature summary extracted from

  • Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
    Fatty acid synthesis and its regulation (1983), Annu. Rev. Biochem., 52, 537-579.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.85 gene sequences Anser sp.
2.3.1.86 transformation technique, plasmid YEpFAS2 transformed to and expressed in Escherichia coli maxi-cells Saccharomyces cerevisiae

General Stability

EC Number General Stability Organism
2.3.1.85 dissociation of native enzyme leads to loss of activity Gallus gallus
2.3.1.85 dissociation of native enzyme leads to loss of activity Mus musculus
2.3.1.85 dissociation of native enzyme leads to loss of activity Homo sapiens
2.3.1.85 dissociation of native enzyme leads to loss of activity Rattus norvegicus
2.3.1.85 dissociation of native enzyme leads to loss of activity Bos taurus
2.3.1.85 dissociation of native enzyme leads to loss of activity Oryctolagus cuniculus
2.3.1.85 dissociation of native enzyme leads to loss of activity Canis lupus familiaris
2.3.1.85 dissociation of native enzyme leads to loss of activity Anser sp.
2.3.1.85 dissociation of native enzyme leads to loss of activity Columba sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 1,3-Dibromo-2-propanone
-
 Anser sp.
2.3.1.85 1,3-Dibromo-2-propanone
-
 Bos taurus
2.3.1.85 1,3-Dibromo-2-propanone
-
 Canis lupus familiaris
2.3.1.85 1,3-Dibromo-2-propanone
-
 Columba sp.
2.3.1.85 1,3-Dibromo-2-propanone
-
 Gallus gallus
2.3.1.85 1,3-Dibromo-2-propanone
-
 Homo sapiens
2.3.1.85 1,3-Dibromo-2-propanone
-
 Mus musculus
2.3.1.85 1,3-Dibromo-2-propanone
-
 Oryctolagus cuniculus
2.3.1.85 1,3-Dibromo-2-propanone
-
 Rattus norvegicus
2.3.1.85 2,3-Butanedione
-
 Anser sp.
2.3.1.85 diisopropylfluorophosphate
-
 Anser sp.
2.3.1.85 diisopropylfluorophosphate
-
 Bos taurus
2.3.1.85 diisopropylfluorophosphate
-
 Canis lupus familiaris
2.3.1.85 diisopropylfluorophosphate
-
 Columba sp.
2.3.1.85 diisopropylfluorophosphate
-
 Gallus gallus
2.3.1.85 diisopropylfluorophosphate
-
 Homo sapiens
2.3.1.85 diisopropylfluorophosphate
-
 Mus musculus
2.3.1.85 diisopropylfluorophosphate
-
 Oryctolagus cuniculus
2.3.1.85 diisopropylfluorophosphate
-
 Rattus norvegicus
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Anser sp.
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Bos taurus
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Canis lupus familiaris
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Columba sp.
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Gallus gallus
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Homo sapiens
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Mus musculus
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Oryctolagus cuniculus
2.3.1.85 iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Rattus norvegicus
2.3.1.85 Phenylglyoxal
-
 Anser sp.
2.3.1.85 PMSF
-
 Anser sp.
2.3.1.85 PMSF
-
 Bos taurus
2.3.1.85 PMSF
-
 Canis lupus familiaris
2.3.1.85 PMSF
-
 Columba sp.
2.3.1.85 PMSF
-
 Gallus gallus
2.3.1.85 PMSF
-
 Homo sapiens
2.3.1.85 PMSF
-
 Mus musculus
2.3.1.85 PMSF
-
 Oryctolagus cuniculus
2.3.1.85 PMSF
-
 Rattus norvegicus
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Anser sp.
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Bos taurus
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Canis lupus familiaris
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Columba sp.
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Gallus gallus
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Homo sapiens
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Mus musculus
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Oryctolagus cuniculus
2.3.1.85 pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Rattus norvegicus
2.3.1.86 1,3-Dibromo-2-propanone
-
 Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.86 additional information
-
-
 Mycolicibacterium smegmatis
2.3.1.86 additional information
-
 alpha6beta6-complex of multifunctional subunits Saccharomyces cerevisiae
2.3.1.86 additional information
-
 amino acid sequence of acyl-carrier-protein Saccharomyces cerevisiae
2.3.1.86 180000
-
 alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 185000
-
 alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 203000
-
 alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 213000
-
 alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 2400000
-
 sedimentation velocity Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Gallus gallus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Mus musculus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Homo sapiens multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Rattus norvegicus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Bos taurus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Oryctolagus cuniculus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Canis lupus familiaris multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Anser sp. multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Columba sp. multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.86 acetyl-CoA + malonyl-CoA + NADH + NADPH Saccharomyces cerevisiae multifunctional enzyme involved in yeast fat metabolism ?
-
 ?
2.3.1.86 acetyl-CoA + malonyl-CoA + NADH + NADPH Mycolicibacterium smegmatis multifunctional enzyme involved in yeast fat metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Anser sp.
-
 goose
-
2.3.1.85 Bos taurus
-
-
-
2.3.1.85 Canis lupus familiaris
-
-
-
2.3.1.85 Columba sp.
-
 pigeon
-
2.3.1.85 Gallus gallus
-
-
-
2.3.1.85 Homo sapiens
-
-
-
2.3.1.85 Mus musculus
-
-
-
2.3.1.85 Oryctolagus cuniculus
-
-
-
2.3.1.85 Rattus norvegicus
-
-
-
2.3.1.86 Mycolicibacterium smegmatis
-
-
-
2.3.1.86 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.86 isolation of alpha- and beta-subunits Saccharomyces cerevisiae
2.3.1.86 isolation of alpha- and beta-subunits by citraconic and dimethylmaleic anhydride modification Saccharomyces cerevisiae

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Gallus gallus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Mus musculus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Homo sapiens
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Rattus norvegicus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Bos taurus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Oryctolagus cuniculus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Canis lupus familiaris
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Anser sp.
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Columba sp.
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Gallus gallus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Mus musculus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Homo sapiens
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Rattus norvegicus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Bos taurus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Oryctolagus cuniculus
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Canis lupus familiaris
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Anser sp.
a
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Columba sp.
a
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O reaction mechanism Saccharomyces cerevisiae
a
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O reaction mechanism Mycolicibacterium smegmatis
a
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O structure Saccharomyces cerevisiae
a
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O structure and regulation Saccharomyces cerevisiae
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.85 adipose tissue
-
 Mus musculus
-
2.3.1.85 adipose tissue
-
 Rattus norvegicus
-
2.3.1.85 liver
-
 Gallus gallus
-
2.3.1.85 liver
-
 Mus musculus
-
2.3.1.85 liver
-
 Homo sapiens
-
2.3.1.85 liver
-
 Rattus norvegicus
-
2.3.1.85 liver
-
 Bos taurus
-
2.3.1.85 liver
-
 Oryctolagus cuniculus
-
2.3.1.85 liver
-
 Canis lupus familiaris
-
2.3.1.85 liver
-
 Anser sp.
-
2.3.1.85 liver
-
 Columba sp.
-
2.3.1.85 mammary gland
-
 Rattus norvegicus
-
2.3.1.85 mammary gland lactating Oryctolagus cuniculus
-
2.3.1.85 uropygial gland
-
 Anser sp.
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Gallus gallus
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Mus musculus
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Homo sapiens
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Rattus norvegicus
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Bos taurus
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Oryctolagus cuniculus
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Canis lupus familiaris
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Anser sp.
2.3.1.85 0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Columba sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Mus musculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Bos taurus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Canis lupus familiaris palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Columba sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O methylmalonyl-CoA instead of malonyl-CoA yields branched fatty acid, e.g. 2,4,6,8-tetramethyldecanoic acid ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Mus musculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Bos taurus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Canis lupus familiaris palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Columba sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+
-
 Mycolicibacterium smegmatis palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
-
 ?
2.3.1.86 acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ stable multifunctional enzyme complex: carries acetyl-CoA and malonyl-CoA transacylase, beta-ketoacyl reductase, beta-hydroxyacyl dehydrase activities on beta-subunits and condensing enzyme, i.e. beta-ketoacyl synthetase, enoylacyl reductase activities and acyl-carrier-protein components on alpha-subunits Saccharomyces cerevisiae palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O
-
 ?
2.3.1.86 acetyl-CoA + malonyl-CoA + NADH + NADPH multifunctional enzyme involved in yeast fat metabolism Saccharomyces cerevisiae ?
-
 ?
2.3.1.86 acetyl-CoA + malonyl-CoA + NADH + NADPH multifunctional enzyme involved in yeast fat metabolism Mycolicibacterium smegmatis ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.85 More
-
 Mus musculus
2.3.1.85 More
-
 Homo sapiens
2.3.1.85 More
-
 Bos taurus
2.3.1.85 More
-
 Canis lupus familiaris
2.3.1.85 More
-
 Anser sp.
2.3.1.85 More
-
 Columba sp.
2.3.1.85 More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis Oryctolagus cuniculus
2.3.1.85 More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis and an acyl carrier site, arranged in three domains but dimer is the only catalytically active form of fatty acid synthase Rattus norvegicus
2.3.1.85 More condensing enzyme activity requires both subunits Gallus gallus
2.3.1.86 dodecamer alpha6,beta6, 6 * 185000 + 6 * 180000, SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 dodecamer alpha6,beta6, 6 * 213000 + 6 * 203000, Tris-glycine-SDS-PAGE Saccharomyces cerevisiae
2.3.1.86 More
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Gallus gallus
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Mus musculus
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Homo sapiens
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Rattus norvegicus
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Bos taurus
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Oryctolagus cuniculus
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Canis lupus familiaris
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Anser sp.
2.3.1.85 4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Columba sp.
2.3.1.85 additional information no requirement for FMN Gallus gallus
2.3.1.85 additional information no requirement for FMN Mus musculus
2.3.1.85 additional information no requirement for FMN Homo sapiens
2.3.1.85 additional information no requirement for FMN Rattus norvegicus
2.3.1.85 additional information no requirement for FMN Bos taurus
2.3.1.85 additional information no requirement for FMN Oryctolagus cuniculus
2.3.1.85 additional information no requirement for FMN Canis lupus familiaris
2.3.1.85 additional information no requirement for FMN Anser sp.
2.3.1.85 additional information no requirement for FMN Columba sp.
2.3.1.85 NADPH requirement, high specificity Gallus gallus
2.3.1.85 NADPH requirement, high specificity Mus musculus
2.3.1.85 NADPH requirement, high specificity Homo sapiens
2.3.1.85 NADPH requirement, high specificity Rattus norvegicus
2.3.1.85 NADPH requirement, high specificity Bos taurus
2.3.1.85 NADPH requirement, high specificity Oryctolagus cuniculus
2.3.1.85 NADPH requirement, high specificity Canis lupus familiaris
2.3.1.85 NADPH requirement, high specificity Anser sp.
2.3.1.85 NADPH requirement, high specificity Columba sp.
2.3.1.86 4'-phosphopantetheine 4.0-5.0 mol per mol enzyme or about 1 mol per 2 subunits Saccharomyces cerevisiae
2.3.1.86 4'-phosphopantetheine 4.0-5.0 mol per mol enzyme Saccharomyces cerevisiae
2.3.1.86 4'-phosphopantetheine alpha-subunit bears prosthetic group Saccharomyces cerevisiae
2.3.1.86 FMN requirement, enoyl reductase activity, associated with beta-subunit, 6 mol per mol synthetase Saccharomyces cerevisiae
2.3.1.86 NADPH requirement Saccharomyces cerevisiae
2.3.1.86 NADPH requirement Mycolicibacterium smegmatis