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Literature summary extracted from

  • Jernejc, K.; Legisa, M.
    Purification and properties of carnitine acetyltransferase from citric acid producing Aspergillus niger (1996), Appl. Biochem. Biotechnol., 60, 151-158.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 Ca2+
-
 Aspergillus niger
2.3.1.7 Ca2+
-
 Bos taurus
2.3.1.7 Ca2+
-
 Candida tropicalis
2.3.1.7 Ca2+
-
 Homo sapiens
2.3.1.7 Ca2+
-
 Saccharomyces cerevisiae
2.3.1.7 Cu2+
-
 Aspergillus niger
2.3.1.7 Hg2+
-
 Bos taurus
2.3.1.7 Hg2+
-
 Sus scrofa
2.3.1.7 Mg2+
-
 Aspergillus niger
2.3.1.7 Mg2+
-
 Candida tropicalis
2.3.1.7 Mg2+
-
 Saccharomyces cerevisiae
2.3.1.7 Mn2+
-
 Aspergillus niger
2.3.1.7 Zn2+
-
 Bos taurus
2.3.1.7 Zn2+
-
 Mus musculus
2.3.1.7 Zn2+
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.09
-
 CoASH mitochondrial enzyme Aspergillus niger
2.3.1.7 0.1
-
 CoASH
-
 Aspergillus niger
2.3.1.7 0.11
-
 CoASH cytosolic enzyme Aspergillus niger
2.3.1.7 1
-
 carnitine mitochondrial enzyme Aspergillus niger
2.3.1.7 1.1
-
 carnitine cytosolic enzyme Aspergillus niger

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 cytosol
-
 Aspergillus niger 5829
-
2.3.1.7 cytosol
-
 Candida tropicalis 5829
-
2.3.1.7 mitochondrion
-
 Mus musculus 5739
-
2.3.1.7 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.7 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.7 mitochondrion
-
 Saccharomyces cerevisiae 5739
-
2.3.1.7 mitochondrion
-
 Aspergillus niger 5739
-
2.3.1.7 mitochondrion
-
 Candida tropicalis 5739
-
2.3.1.7 peroxisome
-
 Mus musculus 5777
-
2.3.1.7 peroxisome
-
 Homo sapiens 5777
-
2.3.1.7 peroxisome
-
 Rattus norvegicus 5777
-
2.3.1.7 peroxisome
-
 Candida tropicalis 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.7 27000
-
 1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE Rattus norvegicus
2.3.1.7 36500
-
 1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE Rattus norvegicus
2.3.1.7 39000
-
 2 * 39000, SDS-PAGE Aspergillus niger
2.3.1.7 60500
-
-
 Homo sapiens
2.3.1.7 62000
-
-
 Rattus norvegicus
2.3.1.7 62000
-
-
 Bos taurus
2.3.1.7 67500
-
 purified from liver homogenate, SDS-PAGE Rattus norvegicus
2.3.1.7 77000
-
 gel filtration Aspergillus niger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Cyberlindnera jadinii
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Mus musculus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Rattus norvegicus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Sus scrofa
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Saccharomyces cerevisiae
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Bos taurus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Aspergillus niger
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Lipomyces starkeyi
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Candida tropicalis
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Cutaneotrichosporon curvatum
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Columba sp.
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Cyberlindnera jadinii
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Mus musculus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Rattus norvegicus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Sus scrofa
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Saccharomyces cerevisiae
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Bos taurus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Aspergillus niger
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Lipomyces starkeyi
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Candida tropicalis
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Cutaneotrichosporon curvatum
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Columba sp.
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Cyberlindnera jadinii
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Mus musculus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Rattus norvegicus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Sus scrofa
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Saccharomyces cerevisiae
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Bos taurus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Aspergillus niger
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Lipomyces starkeyi
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Candida tropicalis
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Cutaneotrichosporon curvatum
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Columba sp.
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Cyberlindnera jadinii
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Mus musculus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Rattus norvegicus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Sus scrofa
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Saccharomyces cerevisiae
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Bos taurus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Aspergillus niger
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Lipomyces starkeyi
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Candida tropicalis
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Cutaneotrichosporon curvatum
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Columba sp.
-
 acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Aspergillus niger
-
 A60 MZKIBK (NRLL 2270)
-
2.3.1.7 Bos taurus
-
 bovine
-
2.3.1.7 Candida tropicalis
-
 yeast
-
2.3.1.7 Columba sp.
-
 pigeon
-
2.3.1.7 Cutaneotrichosporon curvatum
-
-
-
2.3.1.7 Cyberlindnera jadinii
-
-
-
2.3.1.7 Homo sapiens
-
 human
-
2.3.1.7 Lipomyces starkeyi
-
-
-
2.3.1.7 Mus musculus
-
 mouse
-
2.3.1.7 Rattus norvegicus
-
 rat
-
2.3.1.7 Saccharomyces cerevisiae
-
 baker's yeast
-
2.3.1.7 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Candida tropicalis
2.3.1.7 mitochondrial and cytosolic enzyme Aspergillus niger

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 heart
-
 Mus musculus
-
2.3.1.7 heart
-
 Homo sapiens
-
2.3.1.7 heart
-
 Rattus norvegicus
-
2.3.1.7 heart
-
 Sus scrofa
-
2.3.1.7 heart
-
 Bos taurus
-
2.3.1.7 heart
-
 Columba sp.
-
2.3.1.7 liver
-
 Mus musculus
-
2.3.1.7 liver
-
 Homo sapiens
-
2.3.1.7 liver
-
 Rattus norvegicus
-
2.3.1.7 liver
-
 Columba sp.
-
2.3.1.7 mycelium
-
 Aspergillus niger
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.7 10.65
-
-
 Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Cyberlindnera jadinii O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Mus musculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Saccharomyces cerevisiae O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Aspergillus niger O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Lipomyces starkeyi O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Cutaneotrichosporon curvatum O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Cyberlindnera jadinii O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Mus musculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Saccharomyces cerevisiae O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Bos taurus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Aspergillus niger O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Lipomyces starkeyi O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Cutaneotrichosporon curvatum O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Cyberlindnera jadinii acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Mus musculus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Homo sapiens acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Rattus norvegicus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Sus scrofa acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Saccharomyces cerevisiae acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Bos taurus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Aspergillus niger acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Lipomyces starkeyi acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Candida tropicalis acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Cutaneotrichosporon curvatum acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Columba sp. acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Cyberlindnera jadinii acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Mus musculus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Homo sapiens acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Rattus norvegicus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Sus scrofa acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Saccharomyces cerevisiae acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Bos taurus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Aspergillus niger acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Lipomyces starkeyi acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Candida tropicalis acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Cutaneotrichosporon curvatum acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Columba sp. acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Cyberlindnera jadinii acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Mus musculus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Saccharomyces cerevisiae acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Aspergillus niger acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Lipomyces starkeyi acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Cutaneotrichosporon curvatum acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Cyberlindnera jadinii acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Mus musculus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Saccharomyces cerevisiae acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Bos taurus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Aspergillus niger acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Lipomyces starkeyi acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Cutaneotrichosporon curvatum acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + carnitine
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.7 dimer
-
 Candida tropicalis
2.3.1.7 dimer 2 * 39000, SDS-PAGE Aspergillus niger
2.3.1.7 dimer 1 * 36500 + 1 * 27000, purified from mitochondrial fraction, monomeric form converted into dimeric by proteolytic modification after disruption of mitochondria, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CAT
-
 Cyberlindnera jadinii
2.3.1.7 CAT
-
 Mus musculus
2.3.1.7 CAT
-
 Homo sapiens
2.3.1.7 CAT
-
 Rattus norvegicus
2.3.1.7 CAT
-
 Aspergillus niger
2.3.1.7 CAT
-
 Lipomyces starkeyi
2.3.1.7 CAT
-
 Candida tropicalis
2.3.1.7 CAT
-
 Cutaneotrichosporon curvatum
2.3.1.7 CAT
-
 Columba sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.7 7.2
-
-
 Candida tropicalis
2.3.1.7 7.3
-
-
 Aspergillus niger
2.3.1.7 8.7
-
-
 Homo sapiens
2.3.1.7 8.7
-
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.7 0.0046
-
 Cu2+
-
 Aspergillus niger
2.3.1.7 1.5
-
 Mg2+
-
 Aspergillus niger
2.3.1.7 2.6
-
 Ca2+
-
 Aspergillus niger
2.3.1.7 5
-
 Mn2+
-
 Aspergillus niger