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Literature summary extracted from

  • Bloisi, W.; Colombo, I.; Garavaglia, B.; Giardini, R.; Finocchiaro, G.; Didonato, S.
    Purification and properties of carnitine acetyltransferase from human liver (1990), Eur. J. Biochem., 189, 539-546.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.7 medicine
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 Ca2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.0213
-
 acetyl-CoA
-
 Homo sapiens
2.3.1.7 0.028
-
 propionyl-CoA
-
 Homo sapiens
2.3.1.7 0.0435
-
 butyryl-CoA
-
 Homo sapiens
2.3.1.7 0.0503
-
 octanoyl-CoA
-
 Homo sapiens
2.3.1.7 0.0549
-
 hexanoyl-CoA
-
 Homo sapiens
2.3.1.7 0.064
-
 decanoyl-CoA
-
 Homo sapiens
2.3.1.7 0.086
-
 carnitine cosubstrate propionyl-CoA Homo sapiens
2.3.1.7 0.097
-
 carnitine cosubstrate acetyl-CoA Homo sapiens
2.3.1.7 0.12
-
 carnitine cosubstrate hexanoyl-CoA Homo sapiens
2.3.1.7 0.148
-
 carnitine cosubstrate octanoyl-CoA Homo sapiens
2.3.1.7 0.152
-
 carnitine cosubstrate butyryl-CoA Homo sapiens
2.3.1.7 0.42
-
 acetylcarnitine
-
 Homo sapiens
2.3.1.7 0.58
-
 carnitine cosubstrate decanoyl-CoA Homo sapiens
2.3.1.7 0.65
-
 propionylcarnitine
-
 Homo sapiens
2.3.1.7 1.39
-
 octanoylcarnitine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion membrane-bound Homo sapiens 5739
-
2.3.1.7 mitochondrion membrane-bound Rattus norvegicus 5739
-
2.3.1.7 peroxisome
-
 Homo sapiens 5777
-
2.3.1.7 peroxisome
-
 Rattus norvegicus 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.7 60500
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Rattus norvegicus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Sus scrofa
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Rattus norvegicus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Sus scrofa
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Rattus norvegicus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Sus scrofa
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Rattus norvegicus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Sus scrofa
-
 acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Homo sapiens
-
 human
-
2.3.1.7 Rattus norvegicus
-
 rat
-
2.3.1.7 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Homo sapiens
2.3.1.7
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 brain
-
 Homo sapiens
-
2.3.1.7 brain
-
 Rattus norvegicus
-
2.3.1.7 brown adipose tissue
-
 Rattus norvegicus
-
2.3.1.7 fibroblast
-
 Homo sapiens
-
2.3.1.7 heart
-
 Homo sapiens
-
2.3.1.7 heart
-
 Rattus norvegicus
-
2.3.1.7 heart
-
 Sus scrofa
-
2.3.1.7 kidney
-
 Homo sapiens
-
2.3.1.7 kidney
-
 Rattus norvegicus
-
2.3.1.7 kidney
-
 Sus scrofa
-
2.3.1.7 liver
-
 Homo sapiens
-
2.3.1.7 liver
-
 Rattus norvegicus
-
2.3.1.7 nervous system
-
 Rattus norvegicus
-
2.3.1.7 testis
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.7 78.75
-
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.3.1.7 -20°C, when stored in 50% glycerol, maintains its activity unaltered for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Homo sapiens acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Rattus norvegicus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Sus scrofa acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Homo sapiens acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Rattus norvegicus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Sus scrofa acyl-CoA + carnitine
-
 r
2.3.1.7 decanoyl-CoA + carnitine
-
 Rattus norvegicus decanoylcarnitine + CoASH
-
 r
2.3.1.7 decanoyl-CoA + carnitine
-
 Sus scrofa decanoylcarnitine + CoASH
-
 r
2.3.1.7 decanoylcarnitine + CoASH
-
 Homo sapiens decanoyl-CoA + carnitine
-
 r
2.3.1.7 decanoylcarnitine + CoASH
-
 Rattus norvegicus decanoyl-CoA + carnitine
-
 r
2.3.1.7 decanoylcarnitine + CoASH
-
 Sus scrofa decanoyl-CoA + carnitine
-
 r
2.3.1.7 hexanoyl-CoA + L-carnitine
-
 Homo sapiens CoA + O-hexanoyl-L-carnitine
-
 ?
2.3.1.7 additional information palmitoyl-CoA is no substrate Homo sapiens ?
-
 ?
2.3.1.7 n-butyryl-CoA + carnitine
-
 Homo sapiens n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyryl-CoA + carnitine
-
 Rattus norvegicus n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Homo sapiens n-butyryl-CoA + carnitine
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Rattus norvegicus n-butyryl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + carnitine
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Homo sapiens octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Rattus norvegicus octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Homo sapiens octanoyl-CoA + carnitine
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Rattus norvegicus octanoyl-CoA + carnitine
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Homo sapiens propionylcarnitine + CoASH
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Rattus norvegicus propionylcarnitine + CoASH
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Homo sapiens propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Rattus norvegicus propionyl-CoA + L-(-)carnitine
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.7 monomer
-
 Rattus norvegicus
2.3.1.7 monomer 1 * 60500, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.7 8.7
-
-
 Homo sapiens
2.3.1.7 8.7
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.7 6 10
-
 Homo sapiens