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Literature summary extracted from

  • White, H.L.; Wu, J.C.
    Choline and carnitine acetyltransferases of heart (1973), Biochemistry, 12, 841-846.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 Acetylcholine competitively inhibits formation of acetylcarnitine Columba sp.
2.3.1.7 choline competitively inhibits formation of acetylcarnitine Columba sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.4
-
 carnitine
-
 Columba sp.
2.3.1.7 1.1
-
 choline brain enzyme Oryctolagus cuniculus
2.3.1.7 5
-
 choline heart enzyme Oryctolagus cuniculus
2.3.1.7 8.7
-
 choline
-
 Columba sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Oryctolagus cuniculus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Columba sp.
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Oryctolagus cuniculus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Columba sp.
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Oryctolagus cuniculus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Columba sp.
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Oryctolagus cuniculus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Columba sp.
-
 acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Columba sp.
-
 pigeon
-
2.3.1.7 Homo sapiens
-
 human
-
2.3.1.7 Oryctolagus cuniculus
-
 rabbit
-
2.3.1.7 Oryctolagus cuniculus
-
 new Zealand white
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Homo sapiens
2.3.1.7
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 brain
-
 Homo sapiens
-
2.3.1.7 brain
-
 Oryctolagus cuniculus
-
2.3.1.7 heart
-
 Homo sapiens
-
2.3.1.7 heart
-
 Oryctolagus cuniculus
-
2.3.1.7 heart
-
 Columba sp.
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.7 -20°C, 0.05% bovine albumin, repeated thawing and freezing does not significantly affect enzyme activity over a period of several months Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Oryctolagus cuniculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + choline
-
 Oryctolagus cuniculus acetylcholine + CoASH
-
 ?
2.3.1.7 acetyl-CoA + choline
-
 Columba sp. acetylcholine + CoASH
-
 ?
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Oryctolagus cuniculus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Homo sapiens acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Oryctolagus cuniculus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Columba sp. acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Homo sapiens acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Oryctolagus cuniculus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Columba sp. acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Oryctolagus cuniculus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Oryctolagus cuniculus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + carnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CarAc
-
 Oryctolagus cuniculus