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Literature summary extracted from

  • Hurst, J.S.; Bazan, H.E.P.
    The sensitivity of bovine corneal epithelial lyso-PAF acetyltransferase to cyclooxygenase and lipoxygenase inhibitors is independent of arachidonate metabolites (1997), J. Ocul. Pharmacol. Ther., 13, 415-426.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 acetyl-salicylic acid IC50: 1.52 mM Bos taurus
2.3.1.67 ascorbic acid 18.3% inhibition at 1 mM Bos taurus
2.3.1.67 baicalein concentration dependent inhibition, IC50: 0.105 mM Bos taurus
2.3.1.67 ebselen suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 7.7% and 26.6% in presence of glutathione Bos taurus
2.3.1.67 EDTA 67.9 and 72.7% inhibition at 0.5 and 1 mM respectively Bos taurus
2.3.1.67 Fe2+ 31% inhibition at 0.01 mM Bos taurus
2.3.1.67 gallic acid 5.3% inhibition at 0.1 mM Bos taurus
2.3.1.67 glutathione suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 18.9% Bos taurus
2.3.1.67 H2O2 8% inhibition at 1 mM Bos taurus
2.3.1.67 indomethacin IC50: 0.26 mM Bos taurus
2.3.1.67 myricetin suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 17% Bos taurus
2.3.1.67 nordihydroguaiaretic acid concentration dependent inhibition, IC50: 0.075 mM Bos taurus
2.3.1.67 quercetin suppresses alkyl-2-acetyl-sn-glycero-3-phosphocholine synthesis by 8.8% Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 microsome
-
 Bos taurus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 corneal epithelium
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
-
 Bos taurus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 6.9
-
 assay at Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.67 0.075
-
 concentration dependent inhibition, IC50: 0.075 mM Bos taurus nordihydroguaiaretic acid
2.3.1.67 0.105
-
 concentration dependent inhibition, IC50: 0.105 mM Bos taurus baicalein
2.3.1.67 0.26
-
 IC50: 0.26 mM Bos taurus indomethacin
2.3.1.67 1.52
-
 IC50: 1.52 mM Bos taurus acetyl-salicylic acid