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Literature summary extracted from

  • Svetlov, S.I.; Liu, H.; Chao, W.; Olson, M.S.
    Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide (1997), Biochim. Biophys. Acta, 1346, 120-130.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.67 lipopolysaccharide activity increases in a time-dependent fashion, maximal activation at 0.010 mg/ml lipopolysaccharide Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.147 additional information Mus musculus key enzyme responsible for the prolonged generation of lyso-platelet-activating factor that increases capability of CoA-independent transacylation followed by CoA-dependent acetylation of lyso-platelet-activating factor, can sustain the biosynthesis of platelet activating factor in lipopolysaccharide-stimulated IC-21 macrophages ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Mus musculus
-
-
-
2.3.1.147 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 IC-21 cell peritoneal macrophage Mus musculus
-
2.3.1.147 IC-21 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine
-
 Mus musculus CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine
-
 Mus musculus CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine
-
 Mus musculus CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine
-
 ?
2.3.1.67 acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
-
 Mus musculus CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.147 additional information key enzyme responsible for the prolonged generation of lyso-platelet-activating factor that increases capability of CoA-independent transacylation followed by CoA-dependent acetylation of lyso-platelet-activating factor, can sustain the biosynthesis of platelet activating factor in lipopolysaccharide-stimulated IC-21 macrophages Mus musculus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 6.9
-
 assay at Mus musculus