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Literature summary extracted from

  • Roy Baker, R.; Chang, H.y.
    Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: Differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors (1998), Biochim. Biophys. Acta, 1390, 215-224.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 1-acyl-sn-glycero-3-phosphate competitive inhibition for 1-alkyl-sn-glycero-3-phosphate Oryctolagus cuniculus
2.3.1.67 oleic acid 1-acyl lysolipids less inhibited than the 1-alkyl species Oryctolagus cuniculus
2.3.1.67 oleoyl-CoA 45-55% inhibition Oryctolagus cuniculus
2.3.1.67 serine/threonine phosphatase diminishes rates of acetylation for 1-alkyl-sn-glycero-3-phosphocholine and 1-acyl-sn-glycero-3-phosphocholine Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.67 0.009
-
 1-O-alkyl-sn-glycero-3-phosphate
-
 Oryctolagus cuniculus
2.3.1.67 0.011
-
 1-acyl-sn-glycero-3-phosphate
-
 Oryctolagus cuniculus
2.3.1.67 0.018
-
 1-alkyl-sn-glycero-3-phosphocholine
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 nucleus
-
 Oryctolagus cuniculus 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 cerebral cortex
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-acyl-sn-glycero-3-phosphate
-
 Oryctolagus cuniculus CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphate
-
 ?
2.3.1.67 acetyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
 Oryctolagus cuniculus CoA + 2-acetyl-1-acyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine
-
 Oryctolagus cuniculus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphate
-
 Oryctolagus cuniculus CoA + 2-acetyl-1-alkyl-6-phosphate
-
 ?
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine
-
 Oryctolagus cuniculus CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 8.4
-
 assay at Oryctolagus cuniculus