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Literature summary extracted from

  • Ninio, E.; Joly, F.; Bessou, G.
    Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance (1988), Biochim. Biophys. Acta, 963, 288-294.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.67 A23187
-
 Homo sapiens

General Stability

EC Number General Stability Organism
2.3.1.67 1-alkyl-sn-glycero-3-phosphocholine at low concentration and lysophosphatidylcholine stabilizes microsomal preparation Homo sapiens
2.3.1.67 dithiothreitol, 1 mM stabilizes microsomal preparation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine irreversible inhibition dependent of both 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and enzyme concentration Homo sapiens
2.3.1.67 1-O-alkyl-sn-glycero-3-phosphocholine inhibition at high concentrations due to its detergent effect Homo sapiens
2.3.1.67 lysophosphatidylcholine inhibition at high concentrations due to its detergent effect Homo sapiens
2.3.1.67 phenylmethylsulfonyl fluoride 30% inhibition at 50 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 neutrophil polymorphonuclear, ionophore A23187 stimulates Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.67 additional information
-
 influence of phospholipids on specific activity at 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-hexadecyl-2-lyso-sn-glycero-3-phosphocholine 40% higher activity respect to the C18 analogue Homo sapiens CoA + 2-acetyl-1-hexadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + 1-octadecyl-2-lyso-sn-glycero-3-phosphocholine
-
 Homo sapiens CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + acetyl-phosphatidylcholine
-
 Homo sapiens ?
-
 ?
2.3.1.67 acetyl-CoA + lyso-phosphatidylcholine
-
 Homo sapiens CoA + 2-acetyl-1-acylphosphatidylcholine
-
 ?
2.3.1.67 acetyl-CoA + lyso-phosphatidylethanolamine
-
 Homo sapiens CoA + 2-acetyl-1-acyl-phosphatidylethanolamine
-
 ?
2.3.1.67 acetyl-CoA + phosphatidylcholine
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.67 37
-
 85% loss of activity after 2 h, 35% loss of activity after 2 h in the presence of DTT and 1-alkyl-2-lyso-sn-glycero-3-phosphate, microsomal preparation Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 7
-
 assay at Homo sapiens