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Literature summary extracted from

  • Lee, T.C.; Vallari, D.S.; Snyder, F.
    1-Alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase (1992), Methods Enzymol., 209, 396-401.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.67 AMP-dependent protein kinase
-
 Homo sapiens
2.3.1.67 bovine serum albumin optimal concentration of 1-1.5 mg/ml at short incubation periods and 2-2.5 mg bovine serum albumin/ml during longer incubation periods Homo sapiens

General Stability

EC Number General Stability Organism
2.3.1.67 dithiothreitol, 1 mM stabilizes microsomal preparation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 Arachidonoyl-CoA
-
 Homo sapiens
2.3.1.67 diisopropylfluorophosphate
-
 Homo sapiens
2.3.1.67 EGTA
-
 Homo sapiens
2.3.1.67 MgCl2
-
 Homo sapiens
2.3.1.67 MnCl2
-
 Homo sapiens
2.3.1.67 N-ethylmaleimide
-
 Homo sapiens
2.3.1.67 p-bromophenacyl bromide
-
 Homo sapiens
2.3.1.67 p-chloromercuribenzoate
-
 Homo sapiens
2.3.1.67 palmitoyl-CoA
-
 Homo sapiens
2.3.1.67 palmitoyllyso-glycero-3-phosphocholine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.67 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.67 Ca2+ optimal activity at 0.0002 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine Homo sapiens final step in remodelling pathway of PAF biosynthesis CoA + 2-acetyl-1-alkyl-6-phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 HL-60 cell differentiated Homo sapiens
-
2.3.1.67 spleen most abundant Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine final step in remodelling pathway of PAF biosynthesis Homo sapiens CoA + 2-acetyl-1-alkyl-6-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + acyl-lyso-glycero-3-phosphocholine
-
 Homo sapiens CoA + acetyl-acyl-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine
-
 Homo sapiens CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine
-
 Homo sapiens CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-monomethylethanamine
-
 Homo sapiens ?
-
 ?
2.3.1.67 acetyl-CoA + alkyl-lyso-N',N'-dimethylethanamine
-
 Homo sapiens ?
-
 ?
2.3.1.67 acetyl-CoA + alkyl-sn-glycero-3-phosphocholine alkyl-lyso-sn-glycero-3-phosphocholine is preferred to its saturated counterpart as substrate Homo sapiens CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine
-
 Homo sapiens CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine
-
 ?
2.3.1.67 propionyl-CoA + alkyl-lyso-glycero-phosphocholine
-
 Homo sapiens CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 6.9
-
 assay at Homo sapiens
2.3.1.67 6.9
-
 optimal pH Homo sapiens