Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ide, T.; Kano, S.; Murata, M.; Yanagita, T.; Sugano, M.
    Dietary modifications of the biliary bile acid glycine:taurine ratio and activity of hepatic bile acid-CoA:amino acid N-acyltransferase (EC 2.3.1) in the rat (1994), Br. J. Nutr., 72, 93-100.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.65 Pectin dietary pectin relative to cellulose activates, especially the glycine-dependent activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.65 0.8 2.5 taurine
-
 Rattus norvegicus
2.3.1.65 0.83
-
 taurine rats fed with cellulose Rattus norvegicus
2.3.1.65 1.02
-
 taurine rats fed with pectin Rattus norvegicus
2.3.1.65 35 40 glycine
-
 Rattus norvegicus
2.3.1.65 38
-
 glycine rats fed with cellulose Rattus norvegicus
2.3.1.65 40
-
 glycine rats fed with pectin Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.65 additional information in the post-mitochondrial fraction of liver homogenates Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.65 choloyl-CoA + taurine Rattus norvegicus taurine conjugates predominate in rat bile at normal hepatocellular concentrations of glycine and taurine CoA + taurocholate
-
 ?
2.3.1.65 choloyl-CoA + taurine Rattus norvegicus bile acid conjugation CoA + taurocholate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.65 Rattus norvegicus
-
 male Wistar rats, 4 weeks old
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.65 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.65 choloyl-CoA + glycine produces taurine- but little glycine-conjugated bile acid at physiological concentrations of glycine and taurine, dietary manipulations modify the glycine:taurine ratio Rattus norvegicus CoA + glycocholate
-
 ?
2.3.1.65 choloyl-CoA + taurine produces taurine- but little glycine-conjugated bile acid at physiological concentrations of glycine and taurine, dietary manipulations modify the hepatic taurine concentration and glycine:taurine ratio Rattus norvegicus CoA + taurocholate
-
 ?
2.3.1.65 choloyl-CoA + taurine taurine conjugates predominate in rat bile at normal hepatocellular concentrations of glycine and taurine Rattus norvegicus CoA + taurocholate
-
 ?
2.3.1.65 choloyl-CoA + taurine bile acid conjugation Rattus norvegicus CoA + taurocholate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.65 37
-
 assay at Rattus norvegicus