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Literature summary extracted from

  • Wittich, R.M.; Walter, R.D.
    Putrescine N-acetyltransferase in Onchocerca volvulus and Ascaris suum, an enzyme which is involved in polyamine degradation and release of N-acetylputrescine (1990), Mol. Biochem. Parasitol., 38, 13-18.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.57 Berenil competitive with respect to putrescine, i.e. diminazene aceturate Ascaris suum
2.3.1.57 Berenil competitive with respect to putrescine, i.e. diminazene aceturate Onchocerca volvulus
2.3.1.57 Pentamidine weak Ascaris suum
2.3.1.57 Pentamidine weak Onchocerca volvulus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.57 0.25
-
 putrescine
-
 Ascaris suum
2.3.1.57 0.33
-
 putrescine
-
 Onchocerca volvulus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 additional information Ascaris suum enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations ?
-
 ?
2.3.1.57 additional information Onchocerca volvulus enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Ascaris suum
-
 female adults
-
2.3.1.57 Onchocerca volvulus
-
 female adults
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.57 partial Ascaris suum
2.3.1.57 partial Onchocerca volvulus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 ovary
-
 Ascaris suum
-
2.3.1.57 uterus
-
 Ascaris suum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.57 0.0006
-
-
 Onchocerca volvulus
2.3.1.57 0.4
-
-
 Ascaris suum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + 1,5-diaminopentane at 45% of the rate with putrescine Onchocerca volvulus CoA + N1-acetyl-1,5-diaminopentane
-
 ?
2.3.1.57 acetyl-CoA + 1,5-diaminopentane at 39% of the rate with putrescine Ascaris suum CoA + N1-acetyl-1,5-diaminopentane
-
 ?
2.3.1.57 acetyl-CoA + 1,6-diaminohexane at 74% of the rate with putrescine Onchocerca volvulus CoA + N1-acetyl-1,6-diaminohexane
-
 ?
2.3.1.57 acetyl-CoA + 1,6-diaminohexane at 50% of the rate with putrescine Ascaris suum CoA + N1-acetyl-1,6-diaminohexane
-
 ?
2.3.1.57 acetyl-CoA + histamine at about 30% of the rate with putrescine Ascaris suum CoA + N-acetylhistamine
-
 ?
2.3.1.57 acetyl-CoA + histamine at about 30% of the rate with putrescine Onchocerca volvulus CoA + N-acetylhistamine
-
 ?
2.3.1.57 acetyl-CoA + putrescine preference for putrescine Ascaris suum CoA + N-acetylputrescine
-
 ?
2.3.1.57 acetyl-CoA + putrescine preference for putrescine Onchocerca volvulus CoA + N-acetylputrescine
-
 ?
2.3.1.57 acetyl-CoA + spermidine very poor substrate, at 2-4% of the rate with putrescine Ascaris suum CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermidine very poor substrate, at 2-4% of the rate with putrescine Onchocerca volvulus CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine very poor substrate, at 2-4% of the rate with putrescine Ascaris suum CoA + N1-acetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermine very poor substrate, at 2-4% of the rate with putrescine Onchocerca volvulus CoA + N1-acetylspermine
-
 ?
2.3.1.57 additional information not: histone Ascaris suum ?
-
 ?
2.3.1.57 additional information not: histone Onchocerca volvulus ?
-
 ?
2.3.1.57 additional information not: dopamine, serotonin Ascaris suum ?
-
 ?
2.3.1.57 additional information not: dopamine, serotonin Onchocerca volvulus ?
-
 ?
2.3.1.57 additional information enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations Ascaris suum ?
-
 ?
2.3.1.57 additional information enzyme is involved in polyamine degradation and excretion of excessive polyamines, release of N-acetylputrescine, role in the control of polyamine concentrations Onchocerca volvulus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.57 0.0012
-
 Berenil
-
 Ascaris suum
2.3.1.57 0.0042
-
 Berenil
-
 Onchocerca volvulus