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Literature summary extracted from

  • Yamashita, A.; Kawagishi, N.; Miyashita, T.; Nagatsuka, T.; Sugiura, T.; Kume, K.; Shimizu, T.; Waku, K.
    ATP-independent fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent transacylation activity toward lysophosphatidic acid catalyzed by acyl-coenzyme A:lysophosphatidic acid acyltransferase (2001), J. Biol. Chem., 276, 26745-26752.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.51 isopropyl-beta-D-thiogalactopyranoside induction of the enzyme gene Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.51 expression in JC201 Escherichia coli cells Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.51 32000
-
 Western blotting Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate recombinant enzyme can catalyse ATP-independent acyl-CoA synthetic activity and CoA-dependent transacylation activity. Acyl-CoA synthetase is not involved in the process Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 r
2.3.1.51 acyl-CoA + 1-O-alkyl-sn-glycerol 3-phosphate the activity is approximately half of that toward 1-acyl-sn-glycerol 3-phosphate Mus musculus CoA + ?
-
 ?
2.3.1.51 acyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-palmitoyl-2-acyl-sn-glycerol 3-phosphate
-
 r
2.3.1.51 arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 linoleoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-oleoyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 r
2.3.1.51 additional information lysophospholipids such as 1-acyl-sn-glycero-3-phosphocholine, 1-acyl-sn-glycero-3-phosphoethanolamine, 1-acyl-sn-glycero-3-phosphoinositol and lysoplatelet-activating factor do not serve as acyl acceptor substrates. Free fatty acids do not serve as acyl donors. The enzyme shows a broad specificity for acyl-CoAs Mus musculus ?
-
 ?
2.3.1.51 additional information reverse reaction of the enzyme: desulfo-CoA and dephospho-COA do not serve as substrates for acyl-CoA synthesis Mus musculus ?
-
 ?
2.3.1.51 myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.51 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.51 7.4
-
 assay at Mus musculus