Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Perry, D.K.
    Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses (2002), Biochim. Biophys. Acta, 1585, 146-152.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.50 etoposide enhanced activity due to chemotherapy with epotoside as therapeutic agent in Molt-4 leukemic cells Homo sapiens
2.3.1.50 fenretinide up-regulates enzyme activity in neuroblastoma cells Homo sapiens
2.3.1.50 additional information enzyme activity is enhanced under stress and in apoptosis, e.g. in pancreatic cells in a model for diabetes, in case of angiotensin II type receptor occupancy Mus musculus
2.3.1.50 additional information enzyme activity is enhanced under stress and in apoptosis, e.g. in pancreatic cells in a model for diabetes, in case of angiotensin II type receptor occupancy Homo sapiens
2.3.1.50 retinoic acid up-regulates enzyme activity in embryonic carcinoma cell ine PCC7-Mz1 Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.50 genes LCB1 and LCB2, overexpression Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.50 C133V reduced activity Homo sapiens
2.3.1.50 C133Y reduced activity Homo sapiens
2.3.1.50 V144D reduced activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.50 beta-chloro-L-alanine
-
 Homo sapiens
2.3.1.50 beta-chloro-L-alanine
-
 Mus musculus
2.3.1.50 beta-chloro-L-alanine
-
 Saccharomyces cerevisiae
2.3.1.50 L-Cycloserine
-
 Homo sapiens
2.3.1.50 L-Cycloserine
-
 Mus musculus
2.3.1.50 L-Cycloserine
-
 Saccharomyces cerevisiae
2.3.1.50 myriocin
-
 Homo sapiens
2.3.1.50 myriocin
-
 Mus musculus
2.3.1.50 myriocin
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.50 endoplasmic reticulum cytosolic side of the membrane Homo sapiens 5783
-
2.3.1.50 endoplasmic reticulum cytosolic side of the membrane Saccharomyces cerevisiae 5783
-
2.3.1.50 microsome
-
 Homo sapiens
-
-
2.3.1.50 microsome
-
 Saccharomyces cerevisiae
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine Homo sapiens involved in cellular stress response CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Saccharomyces cerevisiae involved in cellular stress response CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Mus musculus first step of biosynthesis of sphingolipid bases CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Homo sapiens first step of biosynthesis of sphingolipid bases CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Saccharomyces cerevisiae first step of biosynthesis of sphingolipid bases CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Homo sapiens rate-limiting enzyme in synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Saccharomyces cerevisiae rate-limiting enzyme in synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Homo sapiens initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine Saccharomyces cerevisiae initial step of de novo ceramide biosynthesis CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.50 Homo sapiens
-
-
-
2.3.1.50 Mus musculus
-
-
-
2.3.1.50 Saccharomyces cerevisiae
-
 lcb1 and lcb2
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.50 palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2 mechanism Homo sapiens
a
2.3.1.50 palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2 mechanism Saccharomyces cerevisiae
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.50 carcinoma cell embryonic cell line PCC7-Mz1 Mus musculus
-
2.3.1.50 cell culture neuroblastoma cell line Homo sapiens
-
2.3.1.50 cell culture leukemia Molt-4 cells Homo sapiens
-
2.3.1.50 keratinocyte
-
 Homo sapiens
-
2.3.1.50 pancreas beta-cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine
-
 Mus musculus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine
-
 Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine involved in cellular stress response Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine involved in cellular stress response Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine first step of biosynthesis of sphingolipid bases Mus musculus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine first step of biosynthesis of sphingolipid bases Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine first step of biosynthesis of sphingolipid bases Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine rate-limiting enzyme in synthesis of sphingolipids Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine rate-limiting enzyme in synthesis of sphingolipids Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine initial step of de novo ceramide biosynthesis Saccharomyces cerevisiae CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.50 More lcb1 and lcb2 are 2 subunits, both necessary for enzyme activity, complexed in ratio 1:1 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.50 pyridoxal 5'-phosphate
-
 Mus musculus
2.3.1.50 pyridoxal 5'-phosphate required for activity Homo sapiens
2.3.1.50 pyridoxal 5'-phosphate required for activity Saccharomyces cerevisiae