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Literature summary extracted from

  • Kelner, D.N.; McCarty, K.S.
    Porcine liver nuclear histone acetyltransferase. Partial purification and basic properties (1984), J. Biol. Chem., 259, 3413-3419.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.48 glycerol protects against thermal denaturation at 37°C Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 iodoacetamide
-
 Sus scrofa
2.3.1.48 K+ 175 mM: 50% inhibition Sus scrofa
2.3.1.48 Mg2+ 37 mM: 50% inhibition Sus scrofa
2.3.1.48 N-ethylmaleimide
-
 Sus scrofa
2.3.1.48 Na+ 160 mM: 50% inhibition Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.48 additional information
-
 additional information
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Sus scrofa 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 94000
-
 gel filtration, glycerol gradient ultracentrifugation Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48 partial Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Sus scrofa CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone chymostatic peptides of histones Sus scrofa CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone H3 histone H3: preferred substrate Sus scrofa CoA + acetylhistone H3
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.48 37
-
 assay at Sus scrofa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.48 37
-
 glycerol protects against thermal denaturation at 37°C Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 7.4
-
 assay at Sus scrofa
2.3.1.48 7.5
-
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.48 6.6 8.4 about 50% of activity maximum at pH 6.6 and pH 8.4 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.48 175
-
 K+
-
 Sus scrofa