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Literature summary extracted from

  • Libby, P.R.
    Calf liver nuclear N-acetyltransferases. Purification and properties of two enzymes with both spermidine acetyltransferase and histone acetyltransferase activities (1978), J. Biol. Chem., 253, 233-237.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 EDTA weak Bos taurus
2.3.1.48 Mg2+ no inhibition Bos taurus
2.3.1.48 Mn2+ no inhibition Bos taurus
2.3.1.48 p-chloromercuribenzoate
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.48 0.009
-
 acetyl-CoA
-
 Bos taurus
2.3.1.48 0.2
-
 spermidine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Bos taurus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.48 additional information addition of Mg2+ and Mn2+ has no effect on activity Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 150000
-
 enzyme form A, gel filtration Bos taurus
2.3.1.48 175000
-
 enzyme form B, gel filtration Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Bos taurus
-
 calf
-
2.3.1.48 Bos taurus
-
 2 enzyme forms: A and B
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48 from calf Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.48 additional information
-
-
 Bos taurus
2.3.1.48 0.00115
-
 enzyme form A Bos taurus
2.3.1.48 0.0014
-
 enzyme form B Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Bos taurus CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + spermidine
-
 Bos taurus ?
-
 ?
2.3.1.48 acetyl-CoA + spermine
-
 Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 7.8
-
-
 Bos taurus
2.3.1.48 8.7
-
 spermidine Bos taurus