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Literature summary extracted from

  • Röhl, F.; Rabenhorst, J.; Zähner, H.
    Biological properties and mode of action of clavams (1987), Arch. Microbiol., 147, 315-320.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.46 glycerol, 30% w/v, stabilizes during purification Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.46 hydroxyethylclavam oxygen analogue beta-lactam antibiotic Escherichia coli
2.3.1.46 L-methionine feed-back inhibition Escherichia coli
2.3.1.46 additional information overview, competitive antagonism of peptides against enzyme inhibition by valclavam; overview, inhibition of several fungi and procaryotes by valclavam Escherichia coli
2.3.1.46 S-adenosyl-L-methionine feed-back inhibition Escherichia coli
2.3.1.46 Valclavam oxygen analogue beta-lactam antibiotic, complete inhibition at 0.2 mM Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.46 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.46
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.46 succinyl-CoA + L-homoserine
-
 Escherichia coli CoA + O-succinyl-L-homoserine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.46 0.00025
-
 hydroxyethylclavam dissociation constant of enzyme-substrate-inhibitor complex Escherichia coli
2.3.1.46 0.00083
-
 Valclavam
-
 Escherichia coli
2.3.1.46 0.00089
-
 Valclavam dissociation constant of enzyme-substrate-inhibitor complex Escherichia coli
2.3.1.46 0.00092
-
 hydroxyethylclavam
-
 Escherichia coli