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Literature summary extracted from

  • Adimoolam, S.; Jin, L.; Grabbe, E.; Shieh, J.J.; Jonas, A.
    Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K) (1998), J. Biol. Chem., 273, 32561-32567.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I the naturally occurring mutant T123I is defective in activation by apo A-I Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.43 expression of the naturally occurring mutants T123I and N228K in COS-1 and CHO cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.43 additional information
-
 additional information Km for two naturally occurring mutant enzymes Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
 activity of the wild-type and two naturally occurring mutant enzymes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 p-nitrophenol butyrate + H2O esterase activity Homo sapiens p-nitrophenol + butyric acid
-
 ?
2.3.1.43 phosphatidylcholine + sterol
-
 Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 ?