Literature summary extracted from

Liu, M.; Subbaiah, P.V.
Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase (1994), Proc. Natl. Acad. Sci. USA, 91, 6035-6039.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.3.1.43	expression in baby hamster kidney cells	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.43	diisopropyl fluorophosphate	inhibits also the hydrolysis of platelet-activating factor by LCAT	Homo sapiens
2.3.1.43	additional information	serum albumin inhibits hydrolysis of platelet-activating factor by LCAT	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.1.43	phosphatidylcholine + sterol	Homo sapiens	-	1-acylglycerophosphocholine + sterol ester	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.43	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.43	plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.43	1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + 1-O-acyl-2-lyso-sn-glycerol-3-phosphocholine	-	Homo sapiens	1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + 1-O-acyl-2-acetyl-sn-glycerol-3-phosphocholine	-	?
2.3.1.43	1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O	hydrolysis of human platelet-activating factor PAF to lyso-PAF	Homo sapiens	1-O-alkyl-2-lyso-sn-glycerol-3-phosphocholine + acetate	-	?
2.3.1.43	phosphatidylcholine + sterol	-	Homo sapiens	1-acylglycerophosphocholine + sterol ester	-	r

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.3.1.43	additional information	hydrolysis of platelet-activating factor by LCAT does not require apolipoprotein as cofactor	Homo sapiens

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Release 2023.1 (January 2023)