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Literature summary extracted from

  • Aron, L.; Jones, S.; Fielding, C.J.
    Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity (1978), J. Biol. Chem., 253, 7220-7226.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 albumin phospholipase activity is dependent on Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 5,5'-dithiobis(2-nitrobenzoic acid)
-
 Homo sapiens
2.3.1.43 Ag+
-
 Homo sapiens
2.3.1.43 lysolecithin inhibition of LCAT activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.43 additional information Ca2+-independent Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.43 Sephadex G-100, hydroxyapatite and affinity column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 0.34
-
 at 37°C in cholesterol-lecithin vesicles Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information phospholipase activity Homo sapiens ?
-
 ?
2.3.1.43 phosphatidylcholine + sterol predominant but incomplete specificity for reaction at position 2 of mixed lecithins Homo sapiens 1-acylglycerophosphocholine + sterol ester
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.43 7.5 8 lecithin-cholesterol acyltransferase activity Homo sapiens
2.3.1.43 8
-
 phospholipase activity Homo sapiens