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Literature summary extracted from

  • Witkowski, A.; Joshi, A.K.; Smith, S.
    Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase (2002), Biochemistry, 41, 10877-10887.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.41 C161Q site-directed mutagenesis, active site Cys mutant, no condensation activity, but 377fold increased decarboxylation activity Rattus norvegicus
2.3.1.41 additional information triple and quadruple mutants of fatty acid synthase complex including mutation sites in the beta-ketoacyl-[acyl-carrier-protein] synthase. e.g. H293A, H331A, K326A,S581A, kinetics, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.41 iodoacetamide kinetics Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.41 additional information
-
additional information mutants Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] mechanism Rattus norvegicus
2.3.1.41 an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] active site cysteine Rattus norvegicus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.41 additional information
-
mutants Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.41 saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Rattus norvegicus 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
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