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Literature summary extracted from

  • Varadharajan, S.; Dhanasekaran, S.; Bonday, Z.Q.; Rangarajan, P.N.; Padmanaban, G.
    Involvement of delta-aminolevulinate synthase encoded by the parasite gene in de novo heme synthesis by Plasmodium falciparum (2002), Biochem. J., 367, 321-327.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.3.1.37 pharmacology enzyme is a target for drug development because of its immunological and inhibitor specificity Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.37 expression in Escherichia coli Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 aminomalonate weak Plasmodium falciparum
2.3.1.37 ethanolamine
-
 Plasmodium falciparum
2.3.1.37 hemin inhibition of the import of the enzyme into the mitochondrial matrix Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.1
-
 succinyl-CoA recombinant enzyme Plasmodium falciparum
2.3.1.37 50
-
 glycine recombinant enzyme Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.37 mitochondrion
-
 Plasmodium falciparum 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 63000
-
 x * 63000, about, SDS-PAGE Plasmodium falciparum
2.3.1.37 158000
-
 gel filtration Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Plasmodium falciparum
-
 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Plasmodium falciparum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 additional information import into mitochondria Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Plasmodium falciparum 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 ? x * 63000, about, SDS-PAGE Plasmodium falciparum