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Literature summary extracted from

  • Hunter, G.A.; Ferreira, G.C.
    Lysine-313 of 5-aminolevulinate synthase acts as a general base during formation of the quinonoid reaction intermediates (1999), Biochemistry, 38, 3711-3718.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.37 K313H formation of quinonoid reaction intermediates Mus musculus
2.3.1.37 K313R formation of quinonoid reaction intermediates Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Mus musculus first step in heme biosynthesis pathway 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine Mus musculus rate-limiting enzyme of heme biosynthesis 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Mus musculus
-
 erythroid-specific isoform
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 mechanism Mus musculus
a
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 Lys313 acts as a general base during formation of the quinonoid reaction intermediates Mus musculus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine first step in heme biosynthesis pathway Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine rate-limiting enzyme of heme biosynthesis Mus musculus 5-aminolevulinate + CoA + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Mus musculus