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Literature summary extracted from

  • Zavgorodnyaya, A.; Papenbrock, J.; Grimm, B.
    Yeast 5-aminolevulinate synthase provides additional chlorophyll precursor in transgenic tobacco (1997), Plant J., 12, 169-178.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.37 nutrition enzyme expressed in transgenic Nicotiana tabacum plants demonstrate functional complementation in the chlorophyll biosynthesis and open strategies for producing tolerance against inhibitors of the C5 pathway Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.37 fusion protein of enzyme and plastid-targeting small subunit of ribulose bisphosphate carboxylase for construction of transgenic plants Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.37 additional information construction of transgenic plants of Nicotiana tabacum wild-type and mutant deficient in chlorophyll biosynthesis expressing the enzyme targeted to the plastids, functional complementation of the mutant, regulation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Saccharomyces cerevisiae key enzyme in tetrapyrrole biosynthesis 5-aminolevulinate + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 additional information
-
 enzyme expressed in transgenic tabacco plants Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Saccharomyces cerevisiae 5-aminolevulinate + CoA + CO2
-
 ?
2.3.1.37 succinyl-CoA + glycine key enzyme in tetrapyrrole biosynthesis Saccharomyces cerevisiae 5-aminolevulinate + CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.37 ALA-S
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate required Saccharomyces cerevisiae