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Literature summary extracted from

  • Munakata, H.; Yamagami, T.; Nagai, T.; Yamamoto, M.; Hayashi, N.
    Purification and structure of rat erythroid-specific delta-aminolevulinate synthase (1993), J. Biochem., 114, 103-111.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.37 ATP slight activation, erythroid-specific isoform Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.37 erythroid-specific isoform ALAS-E, DNA-sequencing and sequence analysis, amino acid sequence determination of precursor protein Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 succinyl-CoA non-specific isoform ALAS-N in absence of ATP Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.002
-
 succinyl-CoA erythroid-specific isoform Rattus norvegicus
2.3.1.37 6.5
-
 glycine erythroid-specific isoform Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 additional information
-
 amino acid sequence determination of the purified protein Rattus norvegicus
2.3.1.37 49000
-
 x * 49000, erythroid-specific isoform, SDS-PAGE Rattus norvegicus
2.3.1.37 64840
-
 erythroid-specific isoform precursor, DNA-sequence determination Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Rattus norvegicus
-
 non-specific, housekeeping isoform ALAS-N and erythroid-specific isoform ALAS-E
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37 erythroid-specific isoform from reticulocytes, papain digestion method Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.37 reticulocyte
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 1.87
-
 purified erythroid-specific isoform Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
 Rattus norvegicus 5-aminolevulinate + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 ? x * 49000, erythroid-specific isoform, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.37 30
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.37 7.6
-
 erythroid-specific isoform Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
 Rattus norvegicus