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Literature summary extracted from

  • Ferreira, G.C.; Dailey, H.A.
    Expression of mammalian 5-aminolevulinate synthase in Escherichia coli. Overproduction, purification, and characterization (1993), J. Biol. Chem., 268, 584-590.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.37 overexpression of mouse erythroid enzyme in Escherichia coli Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.37 0.055
-
succinyl-CoA recombinant protein Mus musculus
2.3.1.37 51
-
glycine recombinant protein Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.37 56000
-
2 * 56000, mouse enzyme expressed in Escherichia coli, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine Mus musculus first step in heme biosynthesis pathway 5-aminolevulinate + CoA + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Mus musculus
-
erythroid-specific isoform
-
2.3.1.37 Mus musculus
-
gene ALAS-2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.37 recombinant from E. coli Mus musculus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.37 additional information
-
-
Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine
-
Mus musculus 5-aminolevulinate + CoA + CO2
-
?
2.3.1.37 succinyl-CoA + glycine first step in heme biosynthesis pathway Mus musculus 5-aminolevulinate + CoA + CO2
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.37 dimer 2 * 56000, mouse enzyme expressed in Escherichia coli, SDS-PAGE Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.37 0.0095
-
succinyl-CoA
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
Mus musculus