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Literature summary extracted from

  • Nandi, D.L.
    Studies on delta-aminolevulinic acid synthase of Rhodopseudomonas spheroides. Reversibility of the reaction, kinetic, spectral, and other studies related to the mechanism of action (1978), J. Biol. Chem., 253, 8872-8877.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.37 aminomalonate competitive versus glycine Cereibacter sphaeroides
2.3.1.37 Aminomethylphosphonate
-
Cereibacter sphaeroides
2.3.1.37 Borohydride aminomalonate protects; in presence of pyridoxal 5'-phosphate Cereibacter sphaeroides
2.3.1.37 additional information product inhibition pattern for the forward reaction and the reverse reaction Cereibacter sphaeroides

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.37 Cereibacter sphaeroides
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.37 succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 mechanism Cereibacter sphaeroides

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.37 succinyl-CoA + glycine glycine is formed by the reverse reaction under optimum conditions at 4-5% the rate of 5-aminolevulinate formed by the forward reaction under optimum conditions Cereibacter sphaeroides 5-aminolevulinate + CoA + CO2
-
r

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.37 pyridoxal 5'-phosphate
-
Cereibacter sphaeroides

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.37 0.023
-
aminomalonate
-
Cereibacter sphaeroides
2.3.1.37 10
-
Aminomethylphosphonate
-
Cereibacter sphaeroides