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Literature summary extracted from

  • Suckling, K.E.; Tocher, D.R.; Smellie, C.G.; Boyd, G.S.
    In vitro regulation of bovine adrenal cortical acyl-CoA: cholesterol acyltransferase and comparison with the rat liver enzyme (1983), Biochim. Biophys. Acta, 753, 422-429.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.26 25-hydroxycholesterol activates Rattus norvegicus
2.3.1.26 25-hydroxycholesterol not stimulatory Bos taurus
2.3.1.26 cholesterol exogenous, not stimulatory Bos taurus
2.3.1.26 cholesterol exogenous, in liposomes or in organic solvent, stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 MgATP2- inhibition of activity Bos taurus
2.3.1.26 MgATP2-
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Rattus norvegicus
-
-
2.3.1.26 microsome
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.26 Ca2+ stimulates Bos taurus
2.3.1.26 Mg2+
-
 Rattus norvegicus
2.3.1.26 Mg2+ stimulates Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Bos taurus
-
-
-
2.3.1.26 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 adrenal gland
-
 Rattus norvegicus
-
2.3.1.26 adrenal gland
-
 Bos taurus
-
2.3.1.26 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.26 0.000089
-
 microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2 + 0.005 mM cAMP + 0.005 mg protein kinase Bos taurus
2.3.1.26 0.000093
-
 microsomes + 5 mM ATP Bos taurus
2.3.1.26 0.000099
-
 microsomes + 5 mM ATP + 50 mM NaF + 5 mM MgCl2 Bos taurus
2.3.1.26 0.000117
-
 control microsomes Bos taurus
2.3.1.26 0.000126
-
 microsomes + 5 mM MgCl2 + 50 mM NaF Bos taurus
2.3.1.26 0.000132
-
 microsomes + 50 mM NaF Bos taurus
2.3.1.26 0.000169
-
 microsomes + 5 mM MgCl2 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester
-
 ?
2.3.1.26 acyl-CoA + cholesterol
-
 Bos taurus CoA + cholesterol ester
-
 ?
2.3.1.26 palmitoyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesteryl palmitate
-
 ?
2.3.1.26 palmitoyl-CoA + cholesterol
-
 Bos taurus CoA + cholesteryl palmitate
-
 ?