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Literature summary extracted from

  • Tavani, D.M.; Nes, W.R.; Billheimer, J.T.
    The sterol substrate specificity of acyl CoA:cholesterol acyltransferase from rat liver (1982), J. Lipid Res., 23, 774-781.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.26 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Rattus norvegicus
-
 male Sprague-Dawley strain
-
2.3.1.26 Rattus norvegicus male Sprague-Dawley
-
 male Sprague-Dawley strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.26 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Rattus norvegicus CoA + cholesterol ester esterification of 3beta-hydroxy group ?
2.3.1.26 additional information structural requirements of sterol substrate Rattus norvegicus ?
-
 ?
2.3.1.26 additional information campesterol is a poor substrate, indicating the alkyl side chain plays an important role in the enzyme reaction Rattus norvegicus ?
-
 ?
2.3.1.26 additional information maximal ester formation is obtained when the longest chain on C-20 has five carbons and either an increase or decrease in the number of carbons reduce the amount of ester formed Rattus norvegicus ?
-
 ?
2.3.1.26 additional information sitosterol, stigmasterol, ergosterol, lanosterol, cycloartenol are not substrates Rattus norvegicus ?
-
 ?
2.3.1.26 additional information 3-epicholesterol is not a substrate, indicating a requirement for a 3beta-hydroxyl group Rattus norvegicus ?
-
 ?
2.3.1.26 additional information structural requirements of sterol substrate Rattus norvegicus male Sprague-Dawley ?
-
 ?
2.3.1.26 additional information campesterol is a poor substrate, indicating the alkyl side chain plays an important role in the enzyme reaction Rattus norvegicus male Sprague-Dawley ?
-
 ?
2.3.1.26 additional information maximal ester formation is obtained when the longest chain on C-20 has five carbons and either an increase or decrease in the number of carbons reduce the amount of ester formed Rattus norvegicus male Sprague-Dawley ?
-
 ?
2.3.1.26 additional information sitosterol, stigmasterol, ergosterol, lanosterol, cycloartenol are not substrates Rattus norvegicus male Sprague-Dawley ?
-
 ?
2.3.1.26 additional information 3-epicholesterol is not a substrate, indicating a requirement for a 3beta-hydroxyl group Rattus norvegicus male Sprague-Dawley ?
-
 ?
2.3.1.26 oleoyl-CoA + 4alpha-methylcholest-7-en-3beta-ol
-
 Rattus norvegicus CoA + 4alpha-methylcholest-7-en 3-oleate
-
 ?
2.3.1.26 oleoyl-CoA + 4alpha-methylcholest-7-en-3beta-ol
-
 Rattus norvegicus CoA + (3beta,4alpha)-4-methylcholest-7-en-3-yl (9Z)-octadec-9-enoate
-
 ?
2.3.1.26 oleoyl-CoA + campesterol 20% of the activity with cholesterol Rattus norvegicus CoA + campesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholest-4-en-3beta-ol low activity Rattus norvegicus CoA + cholest-4-en 3-oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholestanol
-
 Rattus norvegicus CoA + cholestanyl oleate
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol highest activity Rattus norvegicus CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + desmosterol 62% of the activity with cholesterol Rattus norvegicus CoA + desmosteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + lathosterol 41% of the activity with cholesterol Rattus norvegicus CoA + lathosteryl oleate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.26 37
-
 assay at Rattus norvegicus