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Literature summary extracted from

  • Yamashita, S.; Nakaya, N.; Miki, Y.; Numa, S.
    Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes (1975), Proc. Natl. Acad. Sci. USA, 72, 600-603.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.3.1.51 ethylene glycol, 20% v/v, stabilizes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.23 Triton X-100 0.5 mM, 40% inhibition, 2 mM, 92% inhibition Rattus norvegicus
2.3.1.51 Triton X-100 0.5 mM and above Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.23 microsome
-
 Rattus norvegicus
-
-
2.3.1.51 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Rattus norvegicus
-
-
-
2.3.1.51 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.23 solubilized with Triton X-100 Rattus norvegicus
2.3.1.51 partial Rattus norvegicus
2.3.1.51 using solubilization with Triton X-100 and gel filtration, separation from EC 2.3.1.23 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 liver
-
 Rattus norvegicus
-
2.3.1.51 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
 Rattus norvegicus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
 r
2.3.1.23 arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine preferred acyl donors in descending order: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA, very little activity with palmitoyl-CoA, lauroyl-CoA, myristoyl-CoA, palmitolenoyl-CoA and stearoyl-CoA Rattus norvegicus CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
 r
2.3.1.23 arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine preferred acyl donor Rattus norvegicus CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
-
 r
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Rattus norvegicus CoA + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
2.3.1.51 arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate arachidonoyl-CoA is a poor substrate Rattus norvegicus CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate lauroyl-CoA is a poor substrate Rattus norvegicus CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate linoleoyl-CoA is a good substrate but is utilized less efficiently than oleoyl-CoA Rattus norvegicus CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 additional information the enzyme exhibits a considerable selectivity for monoenoic and dienoic fatty acyl-CoA thioesters Rattus norvegicus ?
-
 ?
2.3.1.51 myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate myristoyl-CoA is a poor substrate Rattus norvegicus CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate is the most effective acyl donor Rattus norvegicus CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate palmitoleoyl-CoA is a good substrate but is utilized less efficiently than oleoyl-CoA Rattus norvegicus CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate palmitoyl-CoA is a poor substrate Rattus norvegicus CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate stearoyl-CoA is a poor substrate Rattus norvegicus CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.23 43
-
 half-life: 12 min Rattus norvegicus
2.3.1.51 43
-
 t1/2: 62 min Rattus norvegicus