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Literature summary extracted from

  • Bhat, B.G.; Wang, P.; Coleman, R.A.
    Sphingosine inhibits rat hepatic monoacylglycerol acyltransferase in Triton X-100 mixed micelles and isolated hepatocytes (1995), Biochemistry, 34, 11237-11244.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.22 sphingomyelin stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.22 phytosphingosine
-
 Rattus norvegicus
2.3.1.22 sphinganine
-
 Rattus norvegicus
2.3.1.22 sphingosine IC50 is 9 mol%, inhibits activity in Triton X-100 mixed micelles and isolated hepatocytes Rattus norvegicus
2.3.1.22 Stearylamine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol Rattus norvegicus the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway CoA + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.22 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol the enzyme may be regulated physiologically by specific intermediates of glycerolipid metabolism. In neonatal liver, signal transduction may be linked to the synthesis of complex lipids via the monoacylglycerol pathway Rattus norvegicus CoA + diacylglycerol
-
 ?