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Literature summary extracted from

  • Mostafa, N.; Bhat, B.G.; Coleman, R.A.
    Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver (1993), Biochim. Biophys. Acta, 1169, 189-195.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.22 bovine serum albumin stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.22 2,4,6-Trinitrobenzene sulfonic acid
-
 Rattus norvegicus
2.3.1.22 CaCl2 12.5 mM, 20-30% inhibition Rattus norvegicus
2.3.1.22 HgCl2 0.5 mM, complete inhibition Rattus norvegicus
2.3.1.22 KI 300 mM, 30% inhibition Rattus norvegicus
2.3.1.22 MnCl2 10 mM, 18-25%; 2.5-5 mM, 40% inhibition of enzymne from neonatal liver Rattus norvegicus
2.3.1.22 NEM 2 mM, 12% inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.22 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.22 Mn2+ 2.5-5 mM, stimulates 160%, enzyme from adult liver Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol Rattus norvegicus the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively CoA + diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 liver adult and neonatal, enhanced expression in diabetes Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.22 acyl-CoA + sn-2-monoacylglycerol the enzyme is developmentally expressed, associated with physiological periods characterized by high rates of lipolysis and depends on fatty acids for energy production. During these periods the enzyme may help to retain essential fatty acids selectively Rattus norvegicus CoA + diacylglycerol
-
 ?
2.3.1.22 palmitoyl-CoA + sn-2-monooleoylglycerol
-
 Rattus norvegicus CoA + 1(3)-palmitoyl-2-oleoylglycerol
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.22 51
-
 after microsomes from adult liver are incubated for 13 min, they retain 44% of the control activity. After 13.5 min of heating, neonatal liver microsomes retain 90% of the control activity Rattus norvegicus
2.3.1.22 56
-
 after microsomes from adult liver are incubated for 13 min, they retain 7% of the control activity. After 13.5 min of heating, neonatal liver microsomes retain 57% of the control activity Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.22 7
-
-
 Rattus norvegicus