EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.21 | malonyl-CoA | inhibits CPT I not CPT II; isoforms L-CPT I and M-CPT I | Homo sapiens | |
2.3.1.21 | malonyl-CoA | differences in sensitivity of hepatic and heart enzyme; inhibits CPT I not CPT II; isoforms L-CPT I and M-CPT I | Rattus norvegicus | |
2.3.1.21 | additional information | physiological role of malonyl-CoA in the heart | Homo sapiens | |
2.3.1.21 | additional information | physiological role of malonyl-CoA in the heart | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.21 | additional information | forward reaction by CPT I at outer mitochondrial membrane, transport of acylcarnitine through mitochondrial membrane, reverse reaction at inner face of inner membrane by CPT II, overview | Homo sapiens | - |
- |
2.3.1.21 | additional information | forward reaction by CPT I at outer mitochondrial membrane, transport of acylcarnitine through mitochondrial membrane, reverse reaction at inner face of inner membrane by CPT II, overview | Rattus norvegicus | - |
- |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.21 | 82000 | - |
x * 82000, M-CPT I, SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | acyl-CoA + L-carnitine | Homo sapiens | CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control | CoA + L-acylcarnitine | - |
r | |
2.3.1.21 | acyl-CoA + L-carnitine | Rattus norvegicus | CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control | CoA + L-acylcarnitine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.21 | Homo sapiens | - |
- |
- |
2.3.1.21 | Rattus norvegicus | - |
2 isoforms L-CPT I and M-CPT I | - |
2.3.1.21 | Rattus norvegicus | - |
2 isoforms of CPT I in heart mitochondria, liver L-CPT I, skeletal muscle M-CPT I | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.21 | heart | - |
Homo sapiens | - |
2.3.1.21 | heart | - |
Rattus norvegicus | - |
2.3.1.21 | liver | - |
Homo sapiens | - |
2.3.1.21 | liver | - |
Rattus norvegicus | - |
2.3.1.21 | skeletal muscle | - |
Homo sapiens | - |
2.3.1.21 | skeletal muscle | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | acyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-acylcarnitine | - |
r | |
2.3.1.21 | acyl-CoA + L-carnitine | - |
Rattus norvegicus | CoA + L-acylcarnitine | - |
r | |
2.3.1.21 | acyl-CoA + L-carnitine | CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control | Homo sapiens | CoA + L-acylcarnitine | - |
r | |
2.3.1.21 | acyl-CoA + L-carnitine | CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control | Rattus norvegicus | CoA + L-acylcarnitine | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.21 | ? | x * 82000, M-CPT I, SDS-PAGE | Rattus norvegicus |