Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hertel, K.; Gellerich, F.N.; Hein, W.; Zierz, S.
    Kinetic investigation of carnitine palmitoyltransferases in homogenates of human skeletal muscle using L-amino-carnitine and malonyl-CoA (1999), Adv. Exp. Med. Biol., 466, 87-93.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 L-aminocarnitine inhibition of CPT II not CPT I Homo sapiens
2.3.1.21 malonyl-CoA CPT I; CPT II not inhibited; regulatory role in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
 CPT II
-
2.3.1.21 Homo sapiens
-
 CPT I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 skeletal muscle CPT II Homo sapiens
-
2.3.1.21 skeletal muscle CPT I Homo sapiens
-
2.3.1.21 skeletal muscle Musculus vastus lateralis Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 additional information
-
 CPT I and II activities in muscle biopsis Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 r
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.21 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.21 7.6
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.21 0.0035
-
 L-aminocarnitine CPT II Homo sapiens