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Literature summary extracted from

  • Brown, N.F.; Hill, J.K.; Esser, V.; Kirkland, J.L.; Corkey, B.E.; Foster, D.W.; McGarry, J.D.
    Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes (1997), Biochem. J., 327, 225-231.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Homo sapiens
2.3.1.21 malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Mus musculus
2.3.1.21 malonyl-CoA CPT I; isoforms L-CPT I and M-CPT I Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrial outer membrane CPT I is located in the outer membrane Mus musculus 5741
-
2.3.1.21 mitochondrial outer membrane CPT I is located in the outer membrane Rattus norvegicus 5741
-
2.3.1.21 mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Mus musculus 5739
-
2.3.1.21 mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Homo sapiens 5739
-
2.3.1.21 mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Rattus norvegicus 5739
-
2.3.1.21 mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Mesocricetus auratus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Mesocricetus auratus
-
 CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Mus musculus CPT I, involved in regulation of fatty acid oxidation CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus CPT I, involved in regulation of fatty acid oxidation CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
 2 isoforms M-CPT I and L-CPT I
-
2.3.1.21 Mesocricetus auratus
-
 2 isoforms L-CPT I and M-CPT I
-
2.3.1.21 Mus musculus
-
 2 isoforms L-CPT I and M-CPT I
-
2.3.1.21 Rattus norvegicus
-
 2 isoforms L-CPT I and M-CPT I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 3T3-L1 cell CPT I and CPT II Mus musculus
-
2.3.1.21 adipocyte
-
 Mus musculus
-
2.3.1.21 adipocyte
-
 Homo sapiens
-
2.3.1.21 adipocyte
-
 Rattus norvegicus
-
2.3.1.21 adipocyte
-
 Mesocricetus auratus
-
2.3.1.21 brain low content L-CPT I and CPT II Rattus norvegicus
-
2.3.1.21 brown adipose tissue CPT II, M-CPT I Mesocricetus auratus
-
2.3.1.21 brown adipose tissue CPT II, M-CPT I, L-CPT I Mus musculus
-
2.3.1.21 brown adipose tissue CPT II, M-CPT I, L-CPT I Rattus norvegicus
-
2.3.1.21 heart
-
 Mus musculus
-
2.3.1.21 heart CPT II, M-CPT I and low content of L-CPT I Homo sapiens
-
2.3.1.21 heart CPT II, M-CPT I and low content of L-CPT I Rattus norvegicus
-
2.3.1.21 intestine small and large, L-CPT I and CPT II Rattus norvegicus
-
2.3.1.21 kidney cortex and medulla, L-CPT I and CPT II Rattus norvegicus
-
2.3.1.21 liver
-
 Mus musculus
-
2.3.1.21 liver
-
 Homo sapiens
-
2.3.1.21 liver L-CPT I Rattus norvegicus
-
2.3.1.21 lung low content L-CPT I and CPT II Rattus norvegicus
-
2.3.1.21 additional information not in spleen Rattus norvegicus
-
2.3.1.21 ovary low content of M-CPT I, and higher content of CPT II ad L-CPT I Rattus norvegicus
-
2.3.1.21 pancreatic islet low content of CPT II, no CPT I Rattus norvegicus
-
2.3.1.21 skeletal muscle
-
 Mus musculus
-
2.3.1.21 skeletal muscle M-CPT I Rattus norvegicus
-
2.3.1.21 skeletal muscle CPT II Homo sapiens
-
2.3.1.21 skeletal muscle CPT II Rattus norvegicus
-
2.3.1.21 testis L-CPT I and high content of CPT II and M-CPT I Rattus norvegicus
-
2.3.1.21 white adipose tissue CPT II, M-CPT I Homo sapiens
-
2.3.1.21 white adipose tissue CPT II, M-CPT I, L-CPT I Rattus norvegicus
-
2.3.1.21 white adipose tissue CPT II, M-CPT I, L-CPT I Mesocricetus auratus
-
2.3.1.21 white adipose tissue CPT II, L-CPT I Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.21 0.0013
-
-
 Rattus norvegicus
2.3.1.21 0.0013
-
 cell line 3T3-L1, CPT I, 6 days after differentiation Mus musculus
2.3.1.21 0.0062
-
 cell line 3T3-L1, CPT II, 6 days after differentiation Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Mus musculus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Mesocricetus auratus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine CPT I, involved in regulation of fatty acid oxidation Mus musculus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine CPT I, involved in regulation of fatty acid oxidation Rattus norvegicus CoA + L-acylcarnitine
-
 ?