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Literature summary extracted from

  • Zhu, H.; Shi, J.; Cregg, J.M.; Woldegiorgis, G.
    Reconstitution of highly expressed human heart muscle carnitine palmitoyltransferase I (1997), Biochem. Biophys. Res. Commun., 239, 498-502.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.21 overexpression of M-CPT I in Pichia pastoris, containing about 24 copies of the expression vector Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 malonyl-CoA CPT II not inhibited; CPT I, native and reconstituted in phospholipid micelles Homo sapiens
2.3.1.21 Triton X-100 recombinant CPT I, complete inactivation at 5%, at least partly reversible Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
 M-CPT I
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.21 recombinant M-CPT I from Pichia pastoris Homo sapiens

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.3.1.21 reconstitution of detergent-inactivated recombinant M-CPT I, purified from Pichia pastoris, by removal of detergents in presence of phospholipids Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart M-CPT I Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 ?