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Literature summary extracted from

  • Woeltje, K.F.; Esser, V.; Weis, B.C.; Cox, W.F.; Schroeder, J.G.; Liao, S.L.; Foster, D.W.; McGarry, J.D.
    Inter-tissue and inter-species characteristics of the mitochondrial carnitine palmitoyltransferase enzyme system (1990), J. Biol. Chem., 265, 10714-10719.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 CoA esters of certain oxirane carboxylic acids irreversible, CPT I but not CPT II Homo sapiens
2.3.1.21 CoA esters of certain oxirane carboxylic acids irreversible, CPT I but not CPT II Mus musculus
2.3.1.21 CoA esters of certain oxirane carboxylic acids irreversible, CPT I but not CPT II Platyrrhini
2.3.1.21 CoA esters of certain oxirane carboxylic acids irreversible, CPT I but not CPT II Rattus norvegicus
2.3.1.21 malonyl-CoA CPT I; CPT II not inhibited; reversible inhibition Homo sapiens
2.3.1.21 malonyl-CoA CPT I; CPT II not inhibited; reversible inhibition Mus musculus
2.3.1.21 malonyl-CoA CPT I; CPT II not inhibited; reversible inhibition Platyrrhini
2.3.1.21 malonyl-CoA CPT I; CPT II not inhibited; reversible inhibition Rattus norvegicus
2.3.1.21 octyl glucoside complete loss of CPT I activity, no loss of CPT II activity Homo sapiens
2.3.1.21 octyl glucoside complete loss of CPT I activity, no loss of CPT II activity Mus musculus
2.3.1.21 octyl glucoside complete loss of CPT I activity, no loss of CPT II activity Platyrrhini
2.3.1.21 octyl glucoside complete loss of CPT I activity, no loss of CPT II activity Rattus norvegicus
2.3.1.21 Triton X-100 complete loss of CPT I activity, no loss of CPT II activity Homo sapiens
2.3.1.21 Triton X-100 complete loss of CPT I activity, no loss of CPT II activity Mus musculus
2.3.1.21 Triton X-100 complete loss of CPT I activity, no loss of CPT II activity Platyrrhini
2.3.1.21 Triton X-100 complete loss of CPT I activity, no loss of CPT II activity Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrion
-
 Mus musculus 5739
-
2.3.1.21 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.21 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.21 mitochondrion
-
 Platyrrhini 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Mus musculus
-
 CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine Platyrrhini
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
-
-
2.3.1.21 Mus musculus
-
-
-
2.3.1.21 Platyrrhini
-
-
-
2.3.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 heart
-
 Mus musculus
-
2.3.1.21 heart
-
 Homo sapiens
-
2.3.1.21 heart
-
 Rattus norvegicus
-
2.3.1.21 liver
-
 Mus musculus
-
2.3.1.21 liver
-
 Homo sapiens
-
2.3.1.21 liver
-
 Rattus norvegicus
-
2.3.1.21 liver
-
 Platyrrhini
-
2.3.1.21 skeletal muscle
-
 Mus musculus
-
2.3.1.21 skeletal muscle
-
 Homo sapiens
-
2.3.1.21 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Mus musculus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Platyrrhini CoA + L-acylcarnitine
-
 ?