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Literature summary extracted from

  • Declercq, P.E.; Falck, J.R.; Kuwajima, M.; Tyminski, H.; Foster, D.W.; McGarry, J.D.
    Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors (1987), J. Biol. Chem., 262, 9812-9821.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 2-bromopalmitoyl-CoA irreversible; with addition of carnitine Rattus norvegicus
2.3.1.21 malonyl-CoA reversible inhibition Rattus norvegicus
2.3.1.21 tetradecylglycidyl-CoA and analogues, irreversible Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrial inner membrane inner face of inner membrane Rattus norvegicus 5743
-
2.3.1.21 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 86000
-
 1 * 86000, muscle, SDS-PAGE Rattus norvegicus
2.3.1.21 94000
-
 1 * 94000, liver, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver
-
 Rattus norvegicus
-
2.3.1.21 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
2.3.1.21 acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 r
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 r

Subunits

EC Number Subunits Comment Organism
2.3.1.21 monomer 1 * 94000, liver, SDS-PAGE Rattus norvegicus
2.3.1.21 monomer 1 * 86000, muscle, SDS-PAGE Rattus norvegicus