Literature summary extracted from

Child, C.J.; Shoolingin-Jordan, P.M.
Inactivation of the polyketide synthase, 6-methylsalicylic acid synthase, by the specific modification of Cys-204 of the beta-ketoacyl synthase by the fungal mycotoxin cerulenin (1998), Biochem. J., 330, 933-937.

No PubMed abstract available

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.165	(2S,3R)-2,3-epoxy-4-oxo-7,10-dodecadienoylamide	mycotoxin produced by Cephalosporium caerulens, trivial name cerulenin, 0.2 mM, complete inactivation after approx. 30 min, second-order rate constant for the reaction with 6-methylsalicylic acid synthase: 13.8 M/s, acetyl-CoA protects, site of modification: Cys204	Penicillium griseofulvum
2.3.1.165	iodoacetamide	100 mM, complete inactivation after 45 min, site of modification: Cys204	Penicillium griseofulvum

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.165	Penicillium griseofulvum	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.165	acetyl-CoA + malonyl-CoA + NADPH	-	Penicillium griseofulvum	6-methylsalicylate + CoA + CO2 + NADP+	-	?

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Release 2023.1 (January 2023)