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Literature summary extracted from

  • Dircks, L.K.; Ke, J.; Sul, H.S.
    A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis (1999), J. Biol. Chem., 274, 34728-34734.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.15 E315A 28% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 E315Q 47% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 F313A 17% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 F313Y 88% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R278H 10% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R278K 76% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R279A 101% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R279H 95% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R279K 101% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R318H 2.6% of wild-type mitochondrial acyltransferase activity Mus musculus
2.3.1.15 R318K 11% of wild-type mitochondrial acyltransferase activity Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.15 cyclohexandione 50 mM, almost complete inhibition of mitochondrial acyltransferase Mus musculus
2.3.1.15 Phenylglyoxal 50 mM, approx. 70% inhibition of mitochondrial acyltransferase Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.15 0.0032
-
 palmitoyl-CoA R318A mutant mitochondrial acyltransferase Mus musculus
2.3.1.15 0.0046
-
 palmitoyl-CoA R318K mutant mitochondrial acyltransferase Mus musculus
2.3.1.15 0.011
-
 palmitoyl-CoA wild-type mitochondrial acyltransferase Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.15 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.15 Mus musculus Q61586
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.15 palmitoyl-CoA + sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
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