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Literature summary extracted from

  • Lilly, K.; Bugaisky, G.E.; Umeda, P.K.; Bieber, L.L.
    The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive (1990), Arch. Biochem. Biophys., 280, 167-174.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.3.1.137 quite unstable, labile in Triton X-100 and octylglucoside, stable in 8 mM CHAPS, 200 mM guanidium chloride and 0.5% Tween 20 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.137 etomoxiryl-CoA
-
 Rattus norvegicus
2.3.1.137 malonyl-CoA
-
 Rattus norvegicus
2.3.1.137 palmitoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.137 endoplasmic reticulum rough and smooth Rattus norvegicus 5783
-
2.3.1.137 microsome
-
 Mus musculus
-
-
2.3.1.137 microsome
-
 Rattus norvegicus
-
-
2.3.1.137 mitochondrion
-
 Mus musculus 5739
-
2.3.1.137 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.1.137 peroxisome
-
 Mus musculus 5777
-
2.3.1.137 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine Mus musculus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Homo sapiens
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine Rattus norvegicus Sprague-Dawley
-
 acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA Mus musculus
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Homo sapiens
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus
-
 acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA Rattus norvegicus Sprague-Dawley
-
 acyl-CoA + L-carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.137 Homo sapiens
-
 human
-
2.3.1.137 Mus musculus
-
 mouse
-
2.3.1.137 Rattus norvegicus
-
 rat
-
2.3.1.137 Rattus norvegicus
-
 Sprague-Dawley
-
2.3.1.137 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.137
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.137 liver
-
 Mus musculus
-
2.3.1.137 liver
-
 Homo sapiens
-
2.3.1.137 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
2.3.1.137 -70°C, stable to freezing at for at least 5 months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.137 acyl-CoA + L-carnitine
-
 Mus musculus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Homo sapiens acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-CoA + L-carnitine
-
 Rattus norvegicus Sprague-Dawley acyl-L-carnitine + CoA
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Mus musculus acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Homo sapiens acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus acyl-CoA + L-carnitine
-
 r
2.3.1.137 acyl-L-carnitine + CoA
-
 Rattus norvegicus Sprague-Dawley acyl-CoA + L-carnitine
-
 r
2.3.1.137 palmitoyl-CoA + L-carnitine
-
 Mus musculus L-palmitoyl-L-carnitine + CoA
-
 r
2.3.1.137 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus L-palmitoyl-L-carnitine + CoA
-
 r
2.3.1.137 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus Sprague-Dawley L-palmitoyl-L-carnitine + CoA
-
 r
2.3.1.137 palmitoyl-L-carnitine + CoA
-
 Mus musculus palmitoyl-CoA + L-carnitine
-
 r
2.3.1.137 palmitoyl-L-carnitine + CoA
-
 Rattus norvegicus palmitoyl-CoA + L-carnitine
-
 r
2.3.1.137 palmitoyl-L-carnitine + CoA
-
 Rattus norvegicus Sprague-Dawley palmitoyl-CoA + L-carnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.137 COT
-
 Mus musculus
2.3.1.137 COT
-
 Rattus norvegicus