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Literature summary extracted from

  • Berges, D.A.; DeWolf, W.E.; Dunn, G.L.; Newmann, D.J.; Schmidt, S.J.; Taggart, J.J.; Gilvarg, C.
    Studies on the active site of succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase. Characterization using analogs of tetrahydrodipicolinate (1986), J. Biol. Chem., 261, 6160-6167.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.117 2,6-dihydroxypimelic acid 0.54 mM, 66% inhibition Escherichia coli
2.3.1.117 2-Hydroxytetrahydropyran-2,6-dicarboxylic acid competitive inhibition Escherichia coli
2.3.1.117 2-oxopimelic acid 5 mM, 57% inhibition Escherichia coli
2.3.1.117 4-oxo-(2E,5E)-heptadien-1,7-dioic acid 0.5 mM, 32% inhibition Escherichia coli
2.3.1.117 6-aminocaproic acid 5 mM, 35% inhibition Escherichia coli
2.3.1.117 D-2-aminopimelate competitive vs. L-2-aminopimelate and tetrahydropicolinate Escherichia coli
2.3.1.117 D-2-hydroxypimelic acid 5 mM, 93% inhibition Escherichia coli
2.3.1.117 DL-2-amino-5-thiapimelic acid 5 mM, 75% inhibition Escherichia coli
2.3.1.117 L-2-hydroxypimelic acid 5 mM, 88% inhibition Escherichia coli
2.3.1.117 pimelic acid 5 mM, 43% inhibition Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.117 0.02
-
 tetrahydrodipicolinate
-
 Escherichia coli
2.3.1.117 1
-
 L-2-aminopimelate
-
 Escherichia coli
2.3.1.117 2
-
 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.117 succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid Escherichia coli
-
 CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.117 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.117 succinyl-CoA + (2S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylic acid
-
 Escherichia coli CoA + (2S)-2-[(3-carboxypropanoyl)amino]-6-oxoheptanedioic acid
-
 ?
2.3.1.117 succinyl-CoA + 3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylic acid
-
 Escherichia coli ?
-
 ?
2.3.1.117 succinyl-CoA + 6-amino-2-hydroxypimelic acid
-
 Escherichia coli CoA + N-succinyl-6-amino-2-hydroxypimelate
-
 ?
2.3.1.117 succinyl-CoA + L-2-aminopimelate tetrahydrodipicolinate analogue Escherichia coli CoA + N-succinyl-L-aminopimelate
-
 ?
2.3.1.117 succinyl-CoA + L-6-amino-L-2-hydroxypimelic acid mixture of isomers Escherichia coli CoA + N-succinyl-L-6-amino-L-2-hydroxypimelate
-
 ?
2.3.1.117 succinyl-CoA + tetrahydrodipicolinate
-
 Escherichia coli ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.117 0.000058
-
 2-Hydroxytetrahydropyran-2,6-dicarboxylic acid
-
 Escherichia coli
2.3.1.117 0.31
-
 D-2-aminopimelate vs. L-2-aminopimelate Escherichia coli
2.3.1.117 0.76
-
 D-2-aminopimelate vs. tetrahydropicolinate Escherichia coli