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Literature summary extracted from

  • Schneider, B.L.; Kiupakis, A.K.; Reitzer, L.J.
    Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli (1998), J. Bacteriol., 180, 4278-4286.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.6.1.81 additional information arginine induces the enzyme in cells grown on glucose and arginine Escherichia coli K-12
2.6.1.81 additional information arginine induces the enzyme, glutamine slightly induces the enzyme Klebsiella aerogenes

Protein Variants

EC Number Protein Variants Comment Organism
2.6.1.81 additional information construction of disruption and of overexpression mutants showing reduced and increased enzyme activities compared to the wild-type, respectively Escherichia coli K-12
3.5.3.23 additional information disruption of astB eliminates succinylarginine dihydrolase activity and prevents arginine utilization but does not impair ornithine catabolism Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.81 additional information NH4+ suppresses the enzyme expression, utilization of carbon sources other than glucose that are frequently involved in catabolic repression Escherichia coli K-12
2.6.1.81 additional information NH4+ suppresses the enzyme expression, utilization of carbon sources other than glucose frequently involved catabolic repression Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.71 N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O Escherichia coli fourth enzyme of arginine succinyltransferase pathway N-succinyl-L-glutamate + NADH + H+
-
 ?
2.3.1.109 succinyl-CoA + L-arginine Escherichia coli
-
 CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-arginine Klebsiella aerogenes arginine succinyltransferase pathway CoA + N2-succinyl-L-arginine
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate Klebsiella aerogenes the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nirogen source, other nutrients influence the enzyme expression, overview N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate Escherichia coli K-12 the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nitrogen source, other nutrients influence the enzyme expression, overview N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.71 Escherichia coli
-
-
-
2.3.1.109 Escherichia coli
-
-
-
2.3.1.109 Klebsiella aerogenes
-
-
-
2.6.1.81 Escherichia coli K-12
-
-
-
2.6.1.81 Klebsiella aerogenes
-
-
-
3.5.1.96 Escherichia coli P76215
-
-
3.5.3.23 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.81 from strain W3110, by ammonium sulfate fractionation, ion exchange chromatography, gel filtration, and hydrophobic interaction chromatography Escherichia coli K-12

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.81 culture condition:arginine-grown cell
-
 Klebsiella aerogenes
-
2.6.1.81 culture condition:glucose/arginine-grown cell
-
 Escherichia coli K-12
-
2.6.1.81 additional information Escherichia coli is not able to grow on arginine as sole carbon, energy, and nitrogen source Escherichia coli K-12
-
2.6.1.81 additional information Klebsiella aerogenes is able to grow on arginine as sole carbon, energy, and nitrogen source Klebsiella aerogenes
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.71 N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O fourth enzyme of arginine succinyltransferase pathway Escherichia coli N-succinyl-L-glutamate + NADH + H+
-
 ?
2.3.1.109 succinyl-CoA + L-arginine
-
 Escherichia coli CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-arginine
-
 Klebsiella aerogenes CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-arginine arginine succinyltransferase pathway Klebsiella aerogenes CoA + N2-succinyl-L-arginine
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate
-
 Klebsiella aerogenes N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate
-
 Escherichia coli K-12 N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nirogen source, other nutrients influence the enzyme expression, overview Klebsiella aerogenes N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
2.6.1.81 N2-succinyl-L-ornithine + 2-oxoglutarate the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nitrogen source, other nutrients influence the enzyme expression, overview Escherichia coli K-12 N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
3.5.1.96 additional information only three enzymes of the ammonia-producing arginine succinyltransferase pathway can be measured in wild-type cells grown with ammonia as the sole nitrogen source: succinylarginine dihydrolase, succinylglutamate desuccinylase, and succinylornithine transaminase Escherichia coli ?
-
 ?
3.5.1.96 N-succinyl-L-glutamate + H2O
-
 Escherichia coli succinate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.71 aruD
-
 Escherichia coli
1.2.1.71 AstD
-
 Escherichia coli
1.2.1.71 N-succinylglutamate 5-semialdehyde dehydrogenase
-
 Escherichia coli
1.2.1.71 SGSD
-
 Escherichia coli
1.2.1.71 succinic semialdehyde dehydrogenase
-
 Escherichia coli
1.2.1.71 succinylglutamic semialdehyde dehydrogenase
-
 Escherichia coli
2.6.1.81 SOT
-
 Klebsiella aerogenes
2.6.1.81 SOT
-
 Escherichia coli K-12
2.6.1.81 succinylornithine aminotransferase
-
 Klebsiella aerogenes
2.6.1.81 succinylornithine aminotransferase
-
 Escherichia coli K-12
3.5.3.23 AstB
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.71 NAD+
-
 Escherichia coli
2.6.1.81 pyridoxal 5'-phosphate
-
 Klebsiella aerogenes
2.6.1.81 pyridoxal 5'-phosphate
-
 Escherichia coli K-12

Expression

EC Number Organism Comment Expression
3.5.1.96 Escherichia coli nitrogen limitation induces the enzymes of the ammonia-producing arginine succinyltransferase pathway AST. Maximal induction with arginine as the sole nitrogen source up

General Information

EC Number General Information Comment Organism
3.5.1.96 physiological function final enzyme of the ammonia-producing arginine succinyltransferase pathway AST in Escherichia coli. Overproduction of AST enzymes results in faster growth with arginine and aspartate Escherichia coli