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Literature summary extracted from

  • Fritsche, E.; Humm, A.; Huber, R.
    The ligand-induced structural changes of human L-arginine:glycine amidinotransferase. A mutational and crystallographic study (1999), J. Biol. Chem., 274, 3026-3032.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.4.1 ornithine competitive inhibition Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.4.1 52000 56000 wild-type enzyme AT, mutant ATdelta11, mutant ATdeltaM302, gel filtration Homo sapiens
2.1.4.1 89200
-
 mutant ATDELTA11, calculated molecular mass Homo sapiens
2.1.4.1 90000
-
 mutant ATDELTAM302, sedimentation analysis Homo sapiens
2.1.4.1 90100
-
 mutant ATDELTA11, sedimentation analysis Homo sapiens
2.1.4.1 91600
-
 mutant ATDELTAM302, calculated molecular mass Homo sapiens
2.1.4.1 91800
-
 wild-type enzyme AT, calculated molecular mass Homo sapiens
2.1.4.2 68900
-
 sedimentation analysis Streptomyces griseus
2.1.4.2 80300
-
 calculated molecular mass Streptomyces griseus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.4.1 L-arginine + glycine Homo sapiens
-
 L-ornithine + guanidinoacetate
-
 r
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate Streptomyces griseus
-
 L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.4.1 Homo sapiens
-
 human
-
2.1.4.2 Streptomyces griseus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.4.1 arginine + 3-aminopropionic acid
-
 Homo sapiens 3-guanidinopropionic acid + ornithine
-
 ?
2.1.4.1 arginine + 4-aminobutyric acid
-
 Homo sapiens 4-guanidinobutyric acid + ornithine
-
 ?
2.1.4.1 arginine + delta-aminovaleric acid
-
 Homo sapiens delta-guanidinovaleric acid + ornithine
-
 ?
2.1.4.1 arginine + gamma-aminobutyric acid
-
 Homo sapiens gamma-guanidinobutyric acid + ornithine
-
 ?
2.1.4.1 canavanine + glycine
-
 Homo sapiens guanidinoacetate + canaline
-
 r
2.1.4.1 canavanine + ornithine
-
 Homo sapiens arginine + canaline
-
 r
2.1.4.1 hydroxyguanidine + glycine
-
 Homo sapiens hydroxylamine + guanidinoacetate
-
 ?
2.1.4.1 L-alanine + glycine
-
 Homo sapiens ?
-
 ?
2.1.4.1 L-aminobutyric acid + glycine
-
 Homo sapiens ?
-
 ?
2.1.4.1 L-arginine + glycine
-
 Homo sapiens L-ornithine + guanidinoacetate
-
 r
2.1.4.1 L-norvaline + glycine
-
 Homo sapiens ?
-
 ?
2.1.4.1 additional information homoarginine, alpha-amino-gamma-guanidinobutyric acid and alpha-amino-beta-guanidinopropionic acid are not substrates Homo sapiens ?
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
-
 Streptomyces griseus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?
2.1.4.2 L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
-
 Streptomyces griseus L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
-
 ?